SHC1-ANAPC5 Fusion FISH Probe
The SHC1-ANAPC5 Fusion FISH Probe is used to confirm a fusion of the SHC1 and ANAPC5 genes. The fusion of the SHC1 and ANAPC5 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SHC1-ANAPC5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| SHC1-ANAPC5-20-RERE | 20 (40 μL) | 200 μL |
|
|
| SHC1-ANAPC5-20-REOR | 20 (40 μL) | 200 μL |
|
|
| SHC1-ANAPC5-20-REGO | 20 (40 μL) | 200 μL |
|
|
| SHC1-ANAPC5-20-REGR | 20 (40 μL) | 200 μL |
|
|
| SHC1-ANAPC5-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| SHC1-ANAPC5-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| SHC1-ANAPC5-20-OROR | 20 (40 μL) | 200 μL |
|
|
| SHC1-ANAPC5-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| SHC1-ANAPC5-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| SHC1-ANAPC5-20-GORE | 20 (40 μL) | 200 μL |
|
|
| SHC1-ANAPC5-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| SHC1-ANAPC5-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| SHC1-ANAPC5-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| SHC1-ANAPC5-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| SHC1-ANAPC5-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| SHC1-ANAPC5-20-GROR | 20 (40 μL) | 200 μL |
|
|
| SHC1-ANAPC5-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| SHC1-ANAPC5-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| SHC1-ANAPC5-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| SHC1-ANAPC5-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| SHC1-ANAPC5-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| SHC1-ANAPC5-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| SHC1-ANAPC5-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| SHC1-ANAPC5-20-AQAQ | 20 (40 μL) | 200 μL |
|
SHC1 Gene Summary
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Gene Name: SHC Adaptor Protein 1
Chromosome: CHR1: 154934773 -154946959
Locus: 1q21.3
ANAPC5 Gene Summary
This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008]
Gene Name: Anaphase Promoting Complex Subunit 5
Chromosome: CHR12: 121746047 -121792012
Locus: 12q24.31
Gene Diseases
The SHC1 ANAPC5 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|