SHPK-ATP2A3 Fusion FISH Probe
The SHPK-ATP2A3 Fusion FISH Probe is used to confirm a fusion of the SHPK and ATP2A3 genes. The fusion of the SHPK and ATP2A3 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SHPK-ATP2A3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| SHPK-ATP2A3-20-RERE | 20 (40 μL) | 200 μL |
|
|
| SHPK-ATP2A3-20-REOR | 20 (40 μL) | 200 μL |
|
|
| SHPK-ATP2A3-20-REGO | 20 (40 μL) | 200 μL |
|
|
| SHPK-ATP2A3-20-REGR | 20 (40 μL) | 200 μL |
|
|
| SHPK-ATP2A3-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| SHPK-ATP2A3-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| SHPK-ATP2A3-20-OROR | 20 (40 μL) | 200 μL |
|
|
| SHPK-ATP2A3-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| SHPK-ATP2A3-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| SHPK-ATP2A3-20-GORE | 20 (40 μL) | 200 μL |
|
|
| SHPK-ATP2A3-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| SHPK-ATP2A3-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| SHPK-ATP2A3-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| SHPK-ATP2A3-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| SHPK-ATP2A3-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| SHPK-ATP2A3-20-GROR | 20 (40 μL) | 200 μL |
|
|
| SHPK-ATP2A3-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| SHPK-ATP2A3-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| SHPK-ATP2A3-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| SHPK-ATP2A3-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| SHPK-ATP2A3-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| SHPK-ATP2A3-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| SHPK-ATP2A3-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| SHPK-ATP2A3-20-AQAQ | 20 (40 μL) | 200 μL |
|
ATP2A3 Gene Summary
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: ATPase Sarcoplasmic/endoplasmic Reticulum Ca2+ Transporting 3
Chromosome: CHR17: 3827162 -3867758
Locus: 17p13.2
SHPK Gene Summary
The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. [provided by RefSeq, Jul 2008]
Gene Name: Sedoheptulokinase
Chromosome: CHR17: 3511555 -3539616
Locus: 17p13.2
Gene Diseases
The SHPK ATP2A3 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|