SIM1-ASCC3 Fusion FISH Probe
The SIM1-ASCC3 Fusion FISH Probe is used to confirm a fusion of the SIM1 and ASCC3 genes. The fusion of the SIM1 and ASCC3 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SIM1-ASCC3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SIM1-ASCC3-20-RERE | 20 (40 μL) | 200 μL |
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| SIM1-ASCC3-20-REOR | 20 (40 μL) | 200 μL |
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| SIM1-ASCC3-20-REGO | 20 (40 μL) | 200 μL |
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| SIM1-ASCC3-20-REGR | 20 (40 μL) | 200 μL |
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| SIM1-ASCC3-20-REAQ | 20 (40 μL) | 200 μL |
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| SIM1-ASCC3-20-ORRE | 20 (40 μL) | 200 μL |
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| SIM1-ASCC3-20-OROR | 20 (40 μL) | 200 μL |
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| SIM1-ASCC3-20-ORGO | 20 (40 μL) | 200 μL |
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| SIM1-ASCC3-20-ORAQ | 20 (40 μL) | 200 μL |
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| SIM1-ASCC3-20-GORE | 20 (40 μL) | 200 μL |
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| SIM1-ASCC3-20-GOOR | 20 (40 μL) | 200 μL |
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| SIM1-ASCC3-20-GOGO | 20 (40 μL) | 200 μL |
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| SIM1-ASCC3-20-GOGR | 20 (40 μL) | 200 μL |
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| SIM1-ASCC3-20-GOAQ | 20 (40 μL) | 200 μL |
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| SIM1-ASCC3-20-GRRE | 20 (40 μL) | 200 μL |
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| SIM1-ASCC3-20-GROR | 20 (40 μL) | 200 μL |
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| SIM1-ASCC3-20-GRGO | 20 (40 μL) | 200 μL |
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| SIM1-ASCC3-20-GRGR | 20 (40 μL) | 200 μL |
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| SIM1-ASCC3-20-GRAQ | 20 (40 μL) | 200 μL |
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| SIM1-ASCC3-20-AQRE | 20 (40 μL) | 200 μL |
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| SIM1-ASCC3-20-AQOR | 20 (40 μL) | 200 μL |
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| SIM1-ASCC3-20-AQGO | 20 (40 μL) | 200 μL |
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| SIM1-ASCC3-20-AQGR | 20 (40 μL) | 200 μL |
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| SIM1-ASCC3-20-AQAQ | 20 (40 μL) | 200 μL |
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SIM1 Gene Summary
SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or cognitive disability of Down syndrome. [provided by RefSeq, Jul 2008]
Gene Name: Single-minded Family BHLH Transcription Factor 1
Chromosome: CHR6: 100836749 -100911551
Locus: 6q16.3
ASCC3 Gene Summary
This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Name: Activating Signal Cointegrator 1 Complex Subunit 3
Chromosome: CHR6: 100956607 -101329224
Locus: 6q16.3
Gene Diseases
The SIM1 ASCC3 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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