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SIM2-MORC3 Fusion FISH Probe

The SIM2-MORC3 Fusion FISH Probe is used to confirm a fusion of the SIM2 and MORC3 genes. The fusion of the SIM2 and MORC3 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
SIM2-MORC3-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
SIM2-MORC3-20-RERE 20 (40 μL) 200 μL
SIM2-MORC3-20-REOR 20 (40 μL) 200 μL
SIM2-MORC3-20-REGO 20 (40 μL) 200 μL
SIM2-MORC3-20-REGR 20 (40 μL) 200 μL
SIM2-MORC3-20-REAQ 20 (40 μL) 200 μL
SIM2-MORC3-20-ORRE 20 (40 μL) 200 μL
SIM2-MORC3-20-OROR 20 (40 μL) 200 μL
SIM2-MORC3-20-ORGO 20 (40 μL) 200 μL
SIM2-MORC3-20-ORAQ 20 (40 μL) 200 μL
SIM2-MORC3-20-GORE 20 (40 μL) 200 μL
SIM2-MORC3-20-GOOR 20 (40 μL) 200 μL
SIM2-MORC3-20-GOGO 20 (40 μL) 200 μL
SIM2-MORC3-20-GOGR 20 (40 μL) 200 μL
SIM2-MORC3-20-GOAQ 20 (40 μL) 200 μL
SIM2-MORC3-20-GRRE 20 (40 μL) 200 μL
SIM2-MORC3-20-GROR 20 (40 μL) 200 μL
SIM2-MORC3-20-GRGO 20 (40 μL) 200 μL
SIM2-MORC3-20-GRGR 20 (40 μL) 200 μL
SIM2-MORC3-20-GRAQ 20 (40 μL) 200 μL
SIM2-MORC3-20-AQRE 20 (40 μL) 200 μL
SIM2-MORC3-20-AQOR 20 (40 μL) 200 μL
SIM2-MORC3-20-AQGO 20 (40 μL) 200 μL
SIM2-MORC3-20-AQGR 20 (40 μL) 200 μL
SIM2-MORC3-20-AQAQ 20 (40 μL) 200 μL

SIM2 Gene Summary

This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Gene Name: Single-minded Family BHLH Transcription Factor 2

Chromosome: CHR21: 38071990 -38122510

Locus: 21q22.13

MORC3 Gene Summary

This gene encodes a protein that localizes to the nuclear matrix and forms nuclear bodies via an ATP-dependent mechanism. The protein is predicted to have coiled-coil and zinc finger domains and has RNA binding activity. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016]

Gene Name: MORC Family CW-type Zinc Finger 3

Chromosome: CHR21: 37692486 -37748944

Locus: 21q22.12

Gene Diseases

The SIM2 MORC3 Fusion has been associated with the following diseases:

Disease Name
Esophageal Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.