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SIPA1L2-TRIM11 Fusion FISH Probe

The SIPA1L2-TRIM11 Fusion FISH Probe is used to confirm a fusion of the SIPA1L2 and TRIM11 genes. The fusion of the SIPA1L2 and TRIM11 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
SIPA1L2-TRIM11-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
SIPA1L2-TRIM11-20-RERE 20 (40 μL) 200 μL
SIPA1L2-TRIM11-20-REOR 20 (40 μL) 200 μL
SIPA1L2-TRIM11-20-REGO 20 (40 μL) 200 μL
SIPA1L2-TRIM11-20-REGR 20 (40 μL) 200 μL
SIPA1L2-TRIM11-20-REAQ 20 (40 μL) 200 μL
SIPA1L2-TRIM11-20-ORRE 20 (40 μL) 200 μL
SIPA1L2-TRIM11-20-OROR 20 (40 μL) 200 μL
SIPA1L2-TRIM11-20-ORGO 20 (40 μL) 200 μL
SIPA1L2-TRIM11-20-ORAQ 20 (40 μL) 200 μL
SIPA1L2-TRIM11-20-GORE 20 (40 μL) 200 μL
SIPA1L2-TRIM11-20-GOOR 20 (40 μL) 200 μL
SIPA1L2-TRIM11-20-GOGO 20 (40 μL) 200 μL
SIPA1L2-TRIM11-20-GOGR 20 (40 μL) 200 μL
SIPA1L2-TRIM11-20-GOAQ 20 (40 μL) 200 μL
SIPA1L2-TRIM11-20-GRRE 20 (40 μL) 200 μL
SIPA1L2-TRIM11-20-GROR 20 (40 μL) 200 μL
SIPA1L2-TRIM11-20-GRGO 20 (40 μL) 200 μL
SIPA1L2-TRIM11-20-GRGR 20 (40 μL) 200 μL
SIPA1L2-TRIM11-20-GRAQ 20 (40 μL) 200 μL
SIPA1L2-TRIM11-20-AQRE 20 (40 μL) 200 μL
SIPA1L2-TRIM11-20-AQOR 20 (40 μL) 200 μL
SIPA1L2-TRIM11-20-AQGO 20 (40 μL) 200 μL
SIPA1L2-TRIM11-20-AQGR 20 (40 μL) 200 μL
SIPA1L2-TRIM11-20-AQAQ 20 (40 μL) 200 μL

SIPA1L2 Gene Summary

This gene encodes a member of the signal-induced proliferation-associated 1 like family. Members of this family contain a GTPase activating domain, a PDZ domain and a C-terminal coiled-coil domain with a leucine zipper. A similar protein in rat acts as a GTPases for the small GTPase Rap. [provided by RefSeq, Sep 2015]

Gene Name: Signal Induced Proliferation Associated 1 Like 2

Chromosome: CHR1: 232533711 -232651243

Locus: 1q42.2

TRIM11 Gene Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified. [provided by RefSeq, Jul 2008]

Gene Name: Tripartite Motif Containing 11

Chromosome: CHR1: 228581376 -228594517

Locus: 1q42.13

Gene Diseases

The SIPA1L2 TRIM11 Fusion has been associated with the following diseases:

Disease Name
Prostate Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Cutaneous Melanocytoma With CRTC1-TRIM11 Fusion

Primary intradermal nodular unpigmented tumors in several patients were analyzed for genetic similarities. It was thought that the CRTC1-TRIM11 fusion would be a novel genetic marker for the tumor. FISH analysis was used with our TRIM11 break apart probe to confirm the presence of the gene fusion. Other FISH analysis was done before TRIM11 as "diagnostic molecular testing". Of the five tumors under analysis, each of them did contain the CRTC1-TRIM11 fusion, which was concluded to be specific to the type of nodular tumor being studied.

CRTC1-TRIM11 Fusion Defined Melanocytic Tumors: A Series of Four Cases

Recently, a new entity of cutaneous melanocytic tumor morphologically resembling clear cell sarcoma was identified in 5 adult patients, characterized by CRTC1-TRIM11 gene fusion. In this study, 4 new cases of this malignancy were analyzed using IHC, RNA sequencing, and FISH. TRIM11 rearrangement was verified using Empire Genomics’ break-apart TRIM11 FISH probe. Tumors were all positive for SOX10 and MiTF, mostly positive for S100 protein, and only focally expressed other melanocytic biomarkers (Melan-A and HMB45).