SIRT5-PHACTR1 Fusion FISH Probe
The SIRT5-PHACTR1 Fusion FISH Probe is used to confirm a fusion of the SIRT5 and PHACTR1 genes. The fusion of the SIRT5 and PHACTR1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SIRT5-PHACTR1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SIRT5-PHACTR1-20-RERE | 20 (40 μL) | 200 μL |
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| SIRT5-PHACTR1-20-REOR | 20 (40 μL) | 200 μL |
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| SIRT5-PHACTR1-20-REGO | 20 (40 μL) | 200 μL |
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| SIRT5-PHACTR1-20-REGR | 20 (40 μL) | 200 μL |
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| SIRT5-PHACTR1-20-REAQ | 20 (40 μL) | 200 μL |
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| SIRT5-PHACTR1-20-ORRE | 20 (40 μL) | 200 μL |
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| SIRT5-PHACTR1-20-OROR | 20 (40 μL) | 200 μL |
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| SIRT5-PHACTR1-20-ORGO | 20 (40 μL) | 200 μL |
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| SIRT5-PHACTR1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SIRT5-PHACTR1-20-GORE | 20 (40 μL) | 200 μL |
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| SIRT5-PHACTR1-20-GOOR | 20 (40 μL) | 200 μL |
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| SIRT5-PHACTR1-20-GOGO | 20 (40 μL) | 200 μL |
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| SIRT5-PHACTR1-20-GOGR | 20 (40 μL) | 200 μL |
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| SIRT5-PHACTR1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SIRT5-PHACTR1-20-GRRE | 20 (40 μL) | 200 μL |
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| SIRT5-PHACTR1-20-GROR | 20 (40 μL) | 200 μL |
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| SIRT5-PHACTR1-20-GRGO | 20 (40 μL) | 200 μL |
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| SIRT5-PHACTR1-20-GRGR | 20 (40 μL) | 200 μL |
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| SIRT5-PHACTR1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SIRT5-PHACTR1-20-AQRE | 20 (40 μL) | 200 μL |
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| SIRT5-PHACTR1-20-AQOR | 20 (40 μL) | 200 μL |
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| SIRT5-PHACTR1-20-AQGO | 20 (40 μL) | 200 μL |
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| SIRT5-PHACTR1-20-AQGR | 20 (40 μL) | 200 μL |
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| SIRT5-PHACTR1-20-AQAQ | 20 (40 μL) | 200 μL |
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SIRT5 Gene Summary
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Gene Name: Sirtuin 5
Chromosome: CHR6: 13574760 -13615390
Locus: 6p23
PHACTR1 Gene Summary
The protein encoded by this gene is a member of the phosphatase and actin regulator family of proteins. This family member can bind actin and regulate the reorganization of the actin cytoskeleton. It plays a role in tubule formation and in endothelial cell survival. Polymorphisms in this gene are associated with susceptibility to myocardial infarction, coronary artery disease and cervical artery dissection. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]
Gene Name: Phosphatase And Actin Regulator 1
Chromosome: CHR6: 12717036 -13288075
Locus: 6p24.1
Gene Diseases
The SIRT5 PHACTR1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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