SKIL-TNIK Fusion FISH Probe
The SKIL-TNIK Fusion FISH Probe is used to confirm a fusion of the SKIL and TNIK genes. The fusion of the SKIL and TNIK genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SKIL-TNIK-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SKIL-TNIK-20-RERE | 20 (40 μL) | 200 μL |
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| SKIL-TNIK-20-REOR | 20 (40 μL) | 200 μL |
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| SKIL-TNIK-20-REGO | 20 (40 μL) | 200 μL |
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| SKIL-TNIK-20-REGR | 20 (40 μL) | 200 μL |
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| SKIL-TNIK-20-REAQ | 20 (40 μL) | 200 μL |
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| SKIL-TNIK-20-ORRE | 20 (40 μL) | 200 μL |
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| SKIL-TNIK-20-OROR | 20 (40 μL) | 200 μL |
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| SKIL-TNIK-20-ORGO | 20 (40 μL) | 200 μL |
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| SKIL-TNIK-20-ORAQ | 20 (40 μL) | 200 μL |
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| SKIL-TNIK-20-GORE | 20 (40 μL) | 200 μL |
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| SKIL-TNIK-20-GOOR | 20 (40 μL) | 200 μL |
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| SKIL-TNIK-20-GOGO | 20 (40 μL) | 200 μL |
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| SKIL-TNIK-20-GOGR | 20 (40 μL) | 200 μL |
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| SKIL-TNIK-20-GOAQ | 20 (40 μL) | 200 μL |
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| SKIL-TNIK-20-GRRE | 20 (40 μL) | 200 μL |
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| SKIL-TNIK-20-GROR | 20 (40 μL) | 200 μL |
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| SKIL-TNIK-20-GRGO | 20 (40 μL) | 200 μL |
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| SKIL-TNIK-20-GRGR | 20 (40 μL) | 200 μL |
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| SKIL-TNIK-20-GRAQ | 20 (40 μL) | 200 μL |
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| SKIL-TNIK-20-AQRE | 20 (40 μL) | 200 μL |
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| SKIL-TNIK-20-AQOR | 20 (40 μL) | 200 μL |
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| SKIL-TNIK-20-AQGO | 20 (40 μL) | 200 μL |
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| SKIL-TNIK-20-AQGR | 20 (40 μL) | 200 μL |
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| SKIL-TNIK-20-AQAQ | 20 (40 μL) | 200 μL |
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SKIL Gene Summary
The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: SKI Like Proto-oncogene
Chromosome: CHR3: 170075472 -170110950
Locus: 3q26.2
TNIK Gene Summary
Wnt signaling plays important roles in carcinogenesis and embryonic development. The protein encoded by this gene is a serine/threonine kinase that functions as an activator of the Wnt signaling pathway. Mutations in this gene are associated with an autosomal recessive form of cognitive disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]
Gene Name: TRAF2 And NCK Interacting Kinase
Chromosome: CHR3: 170780291 -171178197
Locus: 3q26.2-q26.31
Gene Diseases
The SKIL TNIK Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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