SLBP-LETM1 Fusion FISH Probe
The SLBP-LETM1 Fusion FISH Probe is used to confirm a fusion of the SLBP and LETM1 genes. The fusion of the SLBP and LETM1 genes has been associated with Head And Neck Squamous Cell Carcinoma , and Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SLBP-LETM1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SLBP-LETM1-20-RERE | 20 (40 μL) | 200 μL |
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| SLBP-LETM1-20-REOR | 20 (40 μL) | 200 μL |
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| SLBP-LETM1-20-REGO | 20 (40 μL) | 200 μL |
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| SLBP-LETM1-20-REGR | 20 (40 μL) | 200 μL |
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| SLBP-LETM1-20-REAQ | 20 (40 μL) | 200 μL |
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| SLBP-LETM1-20-ORRE | 20 (40 μL) | 200 μL |
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| SLBP-LETM1-20-OROR | 20 (40 μL) | 200 μL |
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| SLBP-LETM1-20-ORGO | 20 (40 μL) | 200 μL |
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| SLBP-LETM1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SLBP-LETM1-20-GORE | 20 (40 μL) | 200 μL |
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| SLBP-LETM1-20-GOOR | 20 (40 μL) | 200 μL |
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| SLBP-LETM1-20-GOGO | 20 (40 μL) | 200 μL |
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| SLBP-LETM1-20-GOGR | 20 (40 μL) | 200 μL |
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| SLBP-LETM1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SLBP-LETM1-20-GRRE | 20 (40 μL) | 200 μL |
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| SLBP-LETM1-20-GROR | 20 (40 μL) | 200 μL |
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| SLBP-LETM1-20-GRGO | 20 (40 μL) | 200 μL |
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| SLBP-LETM1-20-GRGR | 20 (40 μL) | 200 μL |
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| SLBP-LETM1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SLBP-LETM1-20-AQRE | 20 (40 μL) | 200 μL |
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| SLBP-LETM1-20-AQOR | 20 (40 μL) | 200 μL |
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| SLBP-LETM1-20-AQGO | 20 (40 μL) | 200 μL |
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| SLBP-LETM1-20-AQGR | 20 (40 μL) | 200 μL |
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| SLBP-LETM1-20-AQAQ | 20 (40 μL) | 200 μL |
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LETM1 Gene Summary
This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19. [provided by RefSeq, Oct 2009]
Gene Name: Leucine Zipper And EF-hand Containing Transmembrane Protein 1
Chromosome: CHR4: 1813205 -1857974
Locus: 4p16.3
SLBP Gene Summary
This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1. [provided by RefSeq, Jul 2008]
Gene Name: Stem-loop Binding Protein
Chromosome: CHR4: 1694526 -1714030
Locus: 4p16.3
Gene Diseases
The SLBP LETM1 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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