SLC35D1-PRKAR2B Fusion FISH Probe
The SLC35D1-PRKAR2B Fusion FISH Probe is used to confirm a fusion of the SLC35D1 and PRKAR2B genes. The fusion of the SLC35D1 and PRKAR2B genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SLC35D1-PRKAR2B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SLC35D1-PRKAR2B-20-RERE | 20 (40 μL) | 200 μL |
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| SLC35D1-PRKAR2B-20-REOR | 20 (40 μL) | 200 μL |
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| SLC35D1-PRKAR2B-20-REGO | 20 (40 μL) | 200 μL |
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| SLC35D1-PRKAR2B-20-REGR | 20 (40 μL) | 200 μL |
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| SLC35D1-PRKAR2B-20-REAQ | 20 (40 μL) | 200 μL |
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| SLC35D1-PRKAR2B-20-ORRE | 20 (40 μL) | 200 μL |
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| SLC35D1-PRKAR2B-20-OROR | 20 (40 μL) | 200 μL |
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| SLC35D1-PRKAR2B-20-ORGO | 20 (40 μL) | 200 μL |
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| SLC35D1-PRKAR2B-20-ORAQ | 20 (40 μL) | 200 μL |
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| SLC35D1-PRKAR2B-20-GORE | 20 (40 μL) | 200 μL |
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| SLC35D1-PRKAR2B-20-GOOR | 20 (40 μL) | 200 μL |
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| SLC35D1-PRKAR2B-20-GOGO | 20 (40 μL) | 200 μL |
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| SLC35D1-PRKAR2B-20-GOGR | 20 (40 μL) | 200 μL |
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| SLC35D1-PRKAR2B-20-GOAQ | 20 (40 μL) | 200 μL |
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| SLC35D1-PRKAR2B-20-GRRE | 20 (40 μL) | 200 μL |
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| SLC35D1-PRKAR2B-20-GROR | 20 (40 μL) | 200 μL |
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| SLC35D1-PRKAR2B-20-GRGO | 20 (40 μL) | 200 μL |
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| SLC35D1-PRKAR2B-20-GRGR | 20 (40 μL) | 200 μL |
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| SLC35D1-PRKAR2B-20-GRAQ | 20 (40 μL) | 200 μL |
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| SLC35D1-PRKAR2B-20-AQRE | 20 (40 μL) | 200 μL |
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| SLC35D1-PRKAR2B-20-AQOR | 20 (40 μL) | 200 μL |
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| SLC35D1-PRKAR2B-20-AQGO | 20 (40 μL) | 200 μL |
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| SLC35D1-PRKAR2B-20-AQGR | 20 (40 μL) | 200 μL |
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| SLC35D1-PRKAR2B-20-AQAQ | 20 (40 μL) | 200 μL |
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PRKAR2B Gene Summary
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008]
Gene Name: Protein Kinase CAMP-dependent Type II Regulatory Subunit Beta
Chromosome: CHR7: 106685177 -106802256
Locus: 7q22.3
SLC35D1 Gene Summary
Glycosylation of cellular glycoconjugates occurs in the endoplasmic reticulum (ER) and Golgi compartment, and requires transport of nucleotide sugars from the cytosol into the lumen of the ER and Golgi by specific transporters. The protein encoded by this gene resides in the ER, and transports both UDP-glucuronic acid (UDP-GlcA) and UDP-N-acetylgalactosamine (UDP-GalNAc) from the cytoplasm to the ER lumen. It may participate in glucuronidation and/or chondroitin sulfate biosynthesis. Mutations in this gene are associated with Schneckenbecken dysplasia.[provided by RefSeq, Sep 2009]
Gene Name: Solute Carrier Family 35 Member D1
Chromosome: CHR1: 67465014 -67520080
Locus: 1p31.3
Gene Diseases
The SLC35D1 PRKAR2B Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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