SLC4A7-TYR Fusion FISH Probe
The SLC4A7-TYR Fusion FISH Probe is used to confirm a fusion of the SLC4A7 and TYR genes. The fusion of the SLC4A7 and TYR genes has been associated with Brain Lower Grade Glioma, and Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SLC4A7-TYR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SLC4A7-TYR-20-RERE | 20 (40 μL) | 200 μL |
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| SLC4A7-TYR-20-REOR | 20 (40 μL) | 200 μL |
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| SLC4A7-TYR-20-REGO | 20 (40 μL) | 200 μL |
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| SLC4A7-TYR-20-REGR | 20 (40 μL) | 200 μL |
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| SLC4A7-TYR-20-REAQ | 20 (40 μL) | 200 μL |
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| SLC4A7-TYR-20-ORRE | 20 (40 μL) | 200 μL |
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| SLC4A7-TYR-20-OROR | 20 (40 μL) | 200 μL |
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| SLC4A7-TYR-20-ORGO | 20 (40 μL) | 200 μL |
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| SLC4A7-TYR-20-ORAQ | 20 (40 μL) | 200 μL |
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| SLC4A7-TYR-20-GORE | 20 (40 μL) | 200 μL |
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| SLC4A7-TYR-20-GOOR | 20 (40 μL) | 200 μL |
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| SLC4A7-TYR-20-GOGO | 20 (40 μL) | 200 μL |
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| SLC4A7-TYR-20-GOGR | 20 (40 μL) | 200 μL |
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| SLC4A7-TYR-20-GOAQ | 20 (40 μL) | 200 μL |
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| SLC4A7-TYR-20-GRRE | 20 (40 μL) | 200 μL |
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| SLC4A7-TYR-20-GROR | 20 (40 μL) | 200 μL |
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| SLC4A7-TYR-20-GRGO | 20 (40 μL) | 200 μL |
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| SLC4A7-TYR-20-GRGR | 20 (40 μL) | 200 μL |
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| SLC4A7-TYR-20-GRAQ | 20 (40 μL) | 200 μL |
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| SLC4A7-TYR-20-AQRE | 20 (40 μL) | 200 μL |
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| SLC4A7-TYR-20-AQOR | 20 (40 μL) | 200 μL |
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| SLC4A7-TYR-20-AQGO | 20 (40 μL) | 200 μL |
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| SLC4A7-TYR-20-AQGR | 20 (40 μL) | 200 μL |
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| SLC4A7-TYR-20-AQAQ | 20 (40 μL) | 200 μL |
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TYR Gene Summary
The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008]
Gene Name: Tyrosinase
Chromosome: CHR11: 88911039 -89028927
Locus: 11q14.3
SLC4A7 Gene Summary
This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012]
Gene Name: Solute Carrier Family 4 Member 7
Chromosome: CHR3: 27414213 -27498245
Locus: 3p24.1
Gene Diseases
The SLC4A7 TYR Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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