SLC6A17-DPYD Fusion FISH Probe
The SLC6A17-DPYD Fusion FISH Probe is used to confirm a fusion of the SLC6A17 and DPYD genes. The fusion of the SLC6A17 and DPYD genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SLC6A17-DPYD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SLC6A17-DPYD-20-RERE | 20 (40 μL) | 200 μL |
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| SLC6A17-DPYD-20-REOR | 20 (40 μL) | 200 μL |
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| SLC6A17-DPYD-20-REGO | 20 (40 μL) | 200 μL |
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| SLC6A17-DPYD-20-REGR | 20 (40 μL) | 200 μL |
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| SLC6A17-DPYD-20-REAQ | 20 (40 μL) | 200 μL |
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| SLC6A17-DPYD-20-ORRE | 20 (40 μL) | 200 μL |
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| SLC6A17-DPYD-20-OROR | 20 (40 μL) | 200 μL |
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| SLC6A17-DPYD-20-ORGO | 20 (40 μL) | 200 μL |
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| SLC6A17-DPYD-20-ORAQ | 20 (40 μL) | 200 μL |
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| SLC6A17-DPYD-20-GORE | 20 (40 μL) | 200 μL |
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| SLC6A17-DPYD-20-GOOR | 20 (40 μL) | 200 μL |
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| SLC6A17-DPYD-20-GOGO | 20 (40 μL) | 200 μL |
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| SLC6A17-DPYD-20-GOGR | 20 (40 μL) | 200 μL |
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| SLC6A17-DPYD-20-GOAQ | 20 (40 μL) | 200 μL |
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| SLC6A17-DPYD-20-GRRE | 20 (40 μL) | 200 μL |
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| SLC6A17-DPYD-20-GROR | 20 (40 μL) | 200 μL |
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| SLC6A17-DPYD-20-GRGO | 20 (40 μL) | 200 μL |
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| SLC6A17-DPYD-20-GRGR | 20 (40 μL) | 200 μL |
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| SLC6A17-DPYD-20-GRAQ | 20 (40 μL) | 200 μL |
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| SLC6A17-DPYD-20-AQRE | 20 (40 μL) | 200 μL |
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| SLC6A17-DPYD-20-AQOR | 20 (40 μL) | 200 μL |
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| SLC6A17-DPYD-20-AQGO | 20 (40 μL) | 200 μL |
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| SLC6A17-DPYD-20-AQGR | 20 (40 μL) | 200 μL |
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| SLC6A17-DPYD-20-AQAQ | 20 (40 μL) | 200 μL |
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DPYD Gene Summary
The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Gene Name: Dihydropyrimidine Dehydrogenase
Chromosome: CHR1: 97543299 -98386615
Locus: 1p21.3
SLC6A17 Gene Summary
The protein encoded by this gene is a member of the SLC6 family of transporters, which are responsible for the presynaptic uptake of most neurotransmitters. The encoded vesicular transporter is selective for proline, glycine, leucine and alanine. In mouse, the strongest expression of this gene was in cortical and hippocampal tissues where expression increased during embryonic brain development and peaked postnatally. Defects in this gene cause a form of autosomal recessive intellectual disability. [provided by RefSeq, Jul 2017]
Gene Name: Solute Carrier Family 6 Member 17
Chromosome: CHR1: 110693131 -110744823
Locus: 1p13.3
Gene Diseases
The SLC6A17 DPYD Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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