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SMG6-VPS53 Fusion FISH Probe

The SMG6-VPS53 Fusion FISH Probe is used to confirm a fusion of the SMG6 and VPS53 genes. The fusion of the SMG6 and VPS53 genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
SMG6-VPS53-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
SMG6-VPS53-20-RERE 20 (40 μL) 200 μL
SMG6-VPS53-20-REOR 20 (40 μL) 200 μL
SMG6-VPS53-20-REGO 20 (40 μL) 200 μL
SMG6-VPS53-20-REGR 20 (40 μL) 200 μL
SMG6-VPS53-20-REAQ 20 (40 μL) 200 μL
SMG6-VPS53-20-ORRE 20 (40 μL) 200 μL
SMG6-VPS53-20-OROR 20 (40 μL) 200 μL
SMG6-VPS53-20-ORGO 20 (40 μL) 200 μL
SMG6-VPS53-20-ORAQ 20 (40 μL) 200 μL
SMG6-VPS53-20-GORE 20 (40 μL) 200 μL
SMG6-VPS53-20-GOOR 20 (40 μL) 200 μL
SMG6-VPS53-20-GOGO 20 (40 μL) 200 μL
SMG6-VPS53-20-GOGR 20 (40 μL) 200 μL
SMG6-VPS53-20-GOAQ 20 (40 μL) 200 μL
SMG6-VPS53-20-GRRE 20 (40 μL) 200 μL
SMG6-VPS53-20-GROR 20 (40 μL) 200 μL
SMG6-VPS53-20-GRGO 20 (40 μL) 200 μL
SMG6-VPS53-20-GRGR 20 (40 μL) 200 μL
SMG6-VPS53-20-GRAQ 20 (40 μL) 200 μL
SMG6-VPS53-20-AQRE 20 (40 μL) 200 μL
SMG6-VPS53-20-AQOR 20 (40 μL) 200 μL
SMG6-VPS53-20-AQGO 20 (40 μL) 200 μL
SMG6-VPS53-20-AQGR 20 (40 μL) 200 μL
SMG6-VPS53-20-AQAQ 20 (40 μL) 200 μL

SMG6 Gene Summary

This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described. [provided by RefSeq, Feb 2014]

Gene Name: SMG6, Nonsense Mediated MRNA Decay Factor

Chromosome: CHR17: 1963132 -2207069

Locus: 17p13.3

VPS53 Gene Summary

This gene encodes a protein with sequence similarity to the yeast Vps53p protein. Vps53p is involved in retrograde vesicle trafficking in late Golgi. [provided by RefSeq, Jul 2008]

Gene Name: VPS53, GARP Complex Subunit

Chromosome: CHR17: 411907 -618096

Locus: 17p13.3

Gene Diseases

The SMG6 VPS53 Fusion has been associated with the following diseases:

Disease Name
Pancreatic Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.