SNIP1-PUM1 Fusion FISH Probe
The SNIP1-PUM1 Fusion FISH Probe is used to confirm a fusion of the SNIP1 and PUM1 genes. The fusion of the SNIP1 and PUM1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SNIP1-PUM1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SNIP1-PUM1-20-RERE | 20 (40 μL) | 200 μL |
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| SNIP1-PUM1-20-REOR | 20 (40 μL) | 200 μL |
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| SNIP1-PUM1-20-REGO | 20 (40 μL) | 200 μL |
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| SNIP1-PUM1-20-REGR | 20 (40 μL) | 200 μL |
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| SNIP1-PUM1-20-REAQ | 20 (40 μL) | 200 μL |
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| SNIP1-PUM1-20-ORRE | 20 (40 μL) | 200 μL |
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| SNIP1-PUM1-20-OROR | 20 (40 μL) | 200 μL |
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| SNIP1-PUM1-20-ORGO | 20 (40 μL) | 200 μL |
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| SNIP1-PUM1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SNIP1-PUM1-20-GORE | 20 (40 μL) | 200 μL |
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| SNIP1-PUM1-20-GOOR | 20 (40 μL) | 200 μL |
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| SNIP1-PUM1-20-GOGO | 20 (40 μL) | 200 μL |
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| SNIP1-PUM1-20-GOGR | 20 (40 μL) | 200 μL |
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| SNIP1-PUM1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SNIP1-PUM1-20-GRRE | 20 (40 μL) | 200 μL |
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| SNIP1-PUM1-20-GROR | 20 (40 μL) | 200 μL |
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| SNIP1-PUM1-20-GRGO | 20 (40 μL) | 200 μL |
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| SNIP1-PUM1-20-GRGR | 20 (40 μL) | 200 μL |
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| SNIP1-PUM1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SNIP1-PUM1-20-AQRE | 20 (40 μL) | 200 μL |
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| SNIP1-PUM1-20-AQOR | 20 (40 μL) | 200 μL |
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| SNIP1-PUM1-20-AQGO | 20 (40 μL) | 200 μL |
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| SNIP1-PUM1-20-AQGR | 20 (40 μL) | 200 μL |
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| SNIP1-PUM1-20-AQAQ | 20 (40 μL) | 200 μL |
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PUM1 Gene Summary
This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: Pumilio RNA Binding Family Member 1
Chromosome: CHR1: 31404352 -31538564
Locus: 1p35.2
SNIP1 Gene Summary
This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits transforming growth factor beta (TGF-beta) and nuclear factor kappa-B (NF-kB) signaling. The encoded protein also regulates the stability of cyclin D1 mRNA, and may play a role in cell proliferation and cancer progression. Mutations in this gene are a cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED). [provided by RefSeq, Mar 2012]
Gene Name: Smad Nuclear Interacting Protein 1
Chromosome: CHR1: 38002141 -38019903
Locus: 1p34.3
Gene Diseases
The SNIP1 PUM1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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