SNTA1-PXMP4 Fusion FISH Probe
The SNTA1-PXMP4 Fusion FISH Probe is used to confirm a fusion of the SNTA1 and PXMP4 genes. The fusion of the SNTA1 and PXMP4 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SNTA1-PXMP4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SNTA1-PXMP4-20-RERE | 20 (40 μL) | 200 μL |
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| SNTA1-PXMP4-20-REOR | 20 (40 μL) | 200 μL |
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| SNTA1-PXMP4-20-REGO | 20 (40 μL) | 200 μL |
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| SNTA1-PXMP4-20-REGR | 20 (40 μL) | 200 μL |
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| SNTA1-PXMP4-20-REAQ | 20 (40 μL) | 200 μL |
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| SNTA1-PXMP4-20-ORRE | 20 (40 μL) | 200 μL |
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| SNTA1-PXMP4-20-OROR | 20 (40 μL) | 200 μL |
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| SNTA1-PXMP4-20-ORGO | 20 (40 μL) | 200 μL |
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| SNTA1-PXMP4-20-ORAQ | 20 (40 μL) | 200 μL |
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| SNTA1-PXMP4-20-GORE | 20 (40 μL) | 200 μL |
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| SNTA1-PXMP4-20-GOOR | 20 (40 μL) | 200 μL |
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| SNTA1-PXMP4-20-GOGO | 20 (40 μL) | 200 μL |
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| SNTA1-PXMP4-20-GOGR | 20 (40 μL) | 200 μL |
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| SNTA1-PXMP4-20-GOAQ | 20 (40 μL) | 200 μL |
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| SNTA1-PXMP4-20-GRRE | 20 (40 μL) | 200 μL |
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| SNTA1-PXMP4-20-GROR | 20 (40 μL) | 200 μL |
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| SNTA1-PXMP4-20-GRGO | 20 (40 μL) | 200 μL |
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| SNTA1-PXMP4-20-GRGR | 20 (40 μL) | 200 μL |
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| SNTA1-PXMP4-20-GRAQ | 20 (40 μL) | 200 μL |
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| SNTA1-PXMP4-20-AQRE | 20 (40 μL) | 200 μL |
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| SNTA1-PXMP4-20-AQOR | 20 (40 μL) | 200 μL |
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| SNTA1-PXMP4-20-AQGO | 20 (40 μL) | 200 μL |
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| SNTA1-PXMP4-20-AQGR | 20 (40 μL) | 200 μL |
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| SNTA1-PXMP4-20-AQAQ | 20 (40 μL) | 200 μL |
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SNTA1 Gene Summary
Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. [provided by RefSeq, Jan 2013]
Gene Name: Syntrophin Alpha 1
Chromosome: CHR20: 31995762 -32031698
Locus: 20q11.21
PXMP4 Gene Summary
The Peroxisomal Membrane Protein 4 (PXMP4) gene is located on chr20 :32290549-32308136 at 20q11.22.
Gene Name: Peroxisomal Membrane Protein 4
Chromosome: CHR20: 32290549 -32308136
Locus: 20q11.22
Gene Diseases
The SNTA1 PXMP4 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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