SOCS6-GLIS3 Fusion FISH Probe
The SOCS6-GLIS3 Fusion FISH Probe is used to confirm a fusion of the SOCS6 and GLIS3 genes. The fusion of the SOCS6 and GLIS3 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SOCS6-GLIS3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SOCS6-GLIS3-20-RERE | 20 (40 μL) | 200 μL |
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| SOCS6-GLIS3-20-REOR | 20 (40 μL) | 200 μL |
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| SOCS6-GLIS3-20-REGO | 20 (40 μL) | 200 μL |
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| SOCS6-GLIS3-20-REGR | 20 (40 μL) | 200 μL |
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| SOCS6-GLIS3-20-REAQ | 20 (40 μL) | 200 μL |
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| SOCS6-GLIS3-20-ORRE | 20 (40 μL) | 200 μL |
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| SOCS6-GLIS3-20-OROR | 20 (40 μL) | 200 μL |
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| SOCS6-GLIS3-20-ORGO | 20 (40 μL) | 200 μL |
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| SOCS6-GLIS3-20-ORAQ | 20 (40 μL) | 200 μL |
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| SOCS6-GLIS3-20-GORE | 20 (40 μL) | 200 μL |
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| SOCS6-GLIS3-20-GOOR | 20 (40 μL) | 200 μL |
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| SOCS6-GLIS3-20-GOGO | 20 (40 μL) | 200 μL |
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| SOCS6-GLIS3-20-GOGR | 20 (40 μL) | 200 μL |
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| SOCS6-GLIS3-20-GOAQ | 20 (40 μL) | 200 μL |
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| SOCS6-GLIS3-20-GRRE | 20 (40 μL) | 200 μL |
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| SOCS6-GLIS3-20-GROR | 20 (40 μL) | 200 μL |
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| SOCS6-GLIS3-20-GRGO | 20 (40 μL) | 200 μL |
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| SOCS6-GLIS3-20-GRGR | 20 (40 μL) | 200 μL |
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| SOCS6-GLIS3-20-GRAQ | 20 (40 μL) | 200 μL |
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| SOCS6-GLIS3-20-AQRE | 20 (40 μL) | 200 μL |
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| SOCS6-GLIS3-20-AQOR | 20 (40 μL) | 200 μL |
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| SOCS6-GLIS3-20-AQGO | 20 (40 μL) | 200 μL |
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| SOCS6-GLIS3-20-AQGR | 20 (40 μL) | 200 μL |
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| SOCS6-GLIS3-20-AQAQ | 20 (40 μL) | 200 μL |
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SOCS6 Gene Summary
The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]
Gene Name: Suppressor Of Cytokine Signaling 6
Chromosome: CHR18: 67956136 -67997434
Locus: 18q22.2
GLIS3 Gene Summary
This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein with five C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the development of pancreatic beta cells, the thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only two have been determined. [provided by RefSeq, Jul 2008]
Gene Name: GLIS Family Zinc Finger 3
Chromosome: CHR9: 3824127 -4300035
Locus: 9p24.2
Gene Diseases
The SOCS6 GLIS3 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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