SORBS2-ELK4 Fusion FISH Probe
The SORBS2-ELK4 Fusion FISH Probe is used to confirm a fusion of the SORBS2 and ELK4 genes. The fusion of the SORBS2 and ELK4 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SORBS2-ELK4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SORBS2-ELK4-20-RERE | 20 (40 μL) | 200 μL |
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| SORBS2-ELK4-20-REOR | 20 (40 μL) | 200 μL |
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| SORBS2-ELK4-20-REGO | 20 (40 μL) | 200 μL |
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| SORBS2-ELK4-20-REGR | 20 (40 μL) | 200 μL |
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| SORBS2-ELK4-20-REAQ | 20 (40 μL) | 200 μL |
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| SORBS2-ELK4-20-ORRE | 20 (40 μL) | 200 μL |
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| SORBS2-ELK4-20-OROR | 20 (40 μL) | 200 μL |
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| SORBS2-ELK4-20-ORGO | 20 (40 μL) | 200 μL |
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| SORBS2-ELK4-20-ORAQ | 20 (40 μL) | 200 μL |
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| SORBS2-ELK4-20-GORE | 20 (40 μL) | 200 μL |
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| SORBS2-ELK4-20-GOOR | 20 (40 μL) | 200 μL |
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| SORBS2-ELK4-20-GOGO | 20 (40 μL) | 200 μL |
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| SORBS2-ELK4-20-GOGR | 20 (40 μL) | 200 μL |
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| SORBS2-ELK4-20-GOAQ | 20 (40 μL) | 200 μL |
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| SORBS2-ELK4-20-GRRE | 20 (40 μL) | 200 μL |
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| SORBS2-ELK4-20-GROR | 20 (40 μL) | 200 μL |
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| SORBS2-ELK4-20-GRGO | 20 (40 μL) | 200 μL |
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| SORBS2-ELK4-20-GRGR | 20 (40 μL) | 200 μL |
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| SORBS2-ELK4-20-GRAQ | 20 (40 μL) | 200 μL |
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| SORBS2-ELK4-20-AQRE | 20 (40 μL) | 200 μL |
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| SORBS2-ELK4-20-AQOR | 20 (40 μL) | 200 μL |
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| SORBS2-ELK4-20-AQGO | 20 (40 μL) | 200 μL |
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| SORBS2-ELK4-20-AQGR | 20 (40 μL) | 200 μL |
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| SORBS2-ELK4-20-AQAQ | 20 (40 μL) | 200 μL |
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ELK4 Gene Summary
This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: ELK4, ETS Transcription Factor
Chromosome: CHR1: 205577070 -205602000
Locus: 1q32.1
SORBS2 Gene Summary
Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Sorbin And SH3 Domain Containing 2
Chromosome: CHR4: 186506597 -186877870
Locus: 4q35.1
Gene Diseases
The SORBS2 ELK4 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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