SORL1-LMNA Fusion FISH Probe
The SORL1-LMNA Fusion FISH Probe is used to confirm a fusion of the SORL1 and LMNA genes. The fusion of the SORL1 and LMNA genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SORL1-LMNA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SORL1-LMNA-20-RERE | 20 (40 μL) | 200 μL |
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| SORL1-LMNA-20-REOR | 20 (40 μL) | 200 μL |
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| SORL1-LMNA-20-REGO | 20 (40 μL) | 200 μL |
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| SORL1-LMNA-20-REGR | 20 (40 μL) | 200 μL |
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| SORL1-LMNA-20-REAQ | 20 (40 μL) | 200 μL |
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| SORL1-LMNA-20-ORRE | 20 (40 μL) | 200 μL |
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| SORL1-LMNA-20-OROR | 20 (40 μL) | 200 μL |
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| SORL1-LMNA-20-ORGO | 20 (40 μL) | 200 μL |
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| SORL1-LMNA-20-ORAQ | 20 (40 μL) | 200 μL |
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| SORL1-LMNA-20-GORE | 20 (40 μL) | 200 μL |
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| SORL1-LMNA-20-GOOR | 20 (40 μL) | 200 μL |
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| SORL1-LMNA-20-GOGO | 20 (40 μL) | 200 μL |
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| SORL1-LMNA-20-GOGR | 20 (40 μL) | 200 μL |
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| SORL1-LMNA-20-GOAQ | 20 (40 μL) | 200 μL |
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| SORL1-LMNA-20-GRRE | 20 (40 μL) | 200 μL |
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| SORL1-LMNA-20-GROR | 20 (40 μL) | 200 μL |
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| SORL1-LMNA-20-GRGO | 20 (40 μL) | 200 μL |
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| SORL1-LMNA-20-GRGR | 20 (40 μL) | 200 μL |
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| SORL1-LMNA-20-GRAQ | 20 (40 μL) | 200 μL |
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| SORL1-LMNA-20-AQRE | 20 (40 μL) | 200 μL |
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| SORL1-LMNA-20-AQOR | 20 (40 μL) | 200 μL |
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| SORL1-LMNA-20-AQGO | 20 (40 μL) | 200 μL |
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| SORL1-LMNA-20-AQGR | 20 (40 μL) | 200 μL |
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| SORL1-LMNA-20-AQAQ | 20 (40 μL) | 200 μL |
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LMNA Gene Summary
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
Gene Name: Lamin A/C
Chromosome: CHR1: 156084460 -156109878
Locus: 1q22
SORL1 Gene Summary
This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded preproprotein is proteolytically processed to generate the mature receptor, which likely plays roles in endocytosis and sorting. Mutations in this gene may be associated with Alzheimer's disease. [provided by RefSeq, Feb 2016]
Gene Name: Sortilin Related Receptor 1
Chromosome: CHR11: 121322911 -121504471
Locus: 11q24.1
Gene Diseases
The SORL1 LMNA Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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