SP3-OLA1 Fusion FISH Probe
The SP3-OLA1 Fusion FISH Probe is used to confirm a fusion of the SP3 and OLA1 genes. The fusion of the SP3 and OLA1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SP3-OLA1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SP3-OLA1-20-RERE | 20 (40 μL) | 200 μL |
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| SP3-OLA1-20-REOR | 20 (40 μL) | 200 μL |
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| SP3-OLA1-20-REGO | 20 (40 μL) | 200 μL |
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| SP3-OLA1-20-REGR | 20 (40 μL) | 200 μL |
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| SP3-OLA1-20-REAQ | 20 (40 μL) | 200 μL |
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| SP3-OLA1-20-ORRE | 20 (40 μL) | 200 μL |
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| SP3-OLA1-20-OROR | 20 (40 μL) | 200 μL |
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| SP3-OLA1-20-ORGO | 20 (40 μL) | 200 μL |
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| SP3-OLA1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SP3-OLA1-20-GORE | 20 (40 μL) | 200 μL |
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| SP3-OLA1-20-GOOR | 20 (40 μL) | 200 μL |
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| SP3-OLA1-20-GOGO | 20 (40 μL) | 200 μL |
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| SP3-OLA1-20-GOGR | 20 (40 μL) | 200 μL |
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| SP3-OLA1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SP3-OLA1-20-GRRE | 20 (40 μL) | 200 μL |
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| SP3-OLA1-20-GROR | 20 (40 μL) | 200 μL |
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| SP3-OLA1-20-GRGO | 20 (40 μL) | 200 μL |
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| SP3-OLA1-20-GRGR | 20 (40 μL) | 200 μL |
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| SP3-OLA1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SP3-OLA1-20-AQRE | 20 (40 μL) | 200 μL |
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| SP3-OLA1-20-AQOR | 20 (40 μL) | 200 μL |
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| SP3-OLA1-20-AQGO | 20 (40 μL) | 200 μL |
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| SP3-OLA1-20-AQGR | 20 (40 μL) | 200 μL |
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| SP3-OLA1-20-AQAQ | 20 (40 μL) | 200 μL |
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SP3 Gene Summary
This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. [provided by RefSeq, Feb 2010]
Gene Name: Sp3 Transcription Factor
Chromosome: CHR2: 174771186 -174830430
Locus: 2q31.1
OLA1 Gene Summary
This gene encodes a member of the GTPase protein family. The encoded protein interacts with breast cancer-associated gene 1 (BRCA1) and BRCA1-associated RING domain protein (BARD1), and is involved in centrosome regulation. Overexpression of this gene has been observed in multiple types of cancer and may be associated with poor survival. Pseudogenes of this gene have been defined on chromosomes 17 and 22. [provided by RefSeq, Jun 2016]
Gene Name: Obg Like ATPase 1
Chromosome: CHR2: 174937174 -175113365
Locus: 2q31.1
Gene Diseases
The SP3 OLA1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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