SPOP-PRDM16 Fusion FISH Probe
The SPOP-PRDM16 Fusion FISH Probe is used to confirm a fusion of the SPOP and PRDM16 genes. The fusion of the SPOP and PRDM16 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SPOP-PRDM16-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SPOP-PRDM16-20-RERE | 20 (40 μL) | 200 μL |
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| SPOP-PRDM16-20-REOR | 20 (40 μL) | 200 μL |
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| SPOP-PRDM16-20-REGO | 20 (40 μL) | 200 μL |
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| SPOP-PRDM16-20-REGR | 20 (40 μL) | 200 μL |
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| SPOP-PRDM16-20-REAQ | 20 (40 μL) | 200 μL |
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| SPOP-PRDM16-20-ORRE | 20 (40 μL) | 200 μL |
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| SPOP-PRDM16-20-OROR | 20 (40 μL) | 200 μL |
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| SPOP-PRDM16-20-ORGO | 20 (40 μL) | 200 μL |
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| SPOP-PRDM16-20-ORAQ | 20 (40 μL) | 200 μL |
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| SPOP-PRDM16-20-GORE | 20 (40 μL) | 200 μL |
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| SPOP-PRDM16-20-GOOR | 20 (40 μL) | 200 μL |
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| SPOP-PRDM16-20-GOGO | 20 (40 μL) | 200 μL |
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| SPOP-PRDM16-20-GOGR | 20 (40 μL) | 200 μL |
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| SPOP-PRDM16-20-GOAQ | 20 (40 μL) | 200 μL |
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| SPOP-PRDM16-20-GRRE | 20 (40 μL) | 200 μL |
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| SPOP-PRDM16-20-GROR | 20 (40 μL) | 200 μL |
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| SPOP-PRDM16-20-GRGO | 20 (40 μL) | 200 μL |
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| SPOP-PRDM16-20-GRGR | 20 (40 μL) | 200 μL |
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| SPOP-PRDM16-20-GRAQ | 20 (40 μL) | 200 μL |
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| SPOP-PRDM16-20-AQRE | 20 (40 μL) | 200 μL |
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| SPOP-PRDM16-20-AQOR | 20 (40 μL) | 200 μL |
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| SPOP-PRDM16-20-AQGO | 20 (40 μL) | 200 μL |
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| SPOP-PRDM16-20-AQGR | 20 (40 μL) | 200 μL |
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| SPOP-PRDM16-20-AQAQ | 20 (40 μL) | 200 μL |
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SPOP Gene Summary
This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Name: Speckle Type BTB/POZ Protein
Chromosome: CHR17: 47676245 -47755525
Locus: 17q21.33
PRDM16 Gene Summary
The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Name: PR/SET Domain 16
Chromosome: CHR1: 2985741 -3355185
Locus: 1p36.32
Gene Diseases
The SPOP PRDM16 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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