SPOP-RARA Fusion FISH Probe
The SPOP-RARA Fusion FISH Probe is used to confirm a fusion of the SPOP and RARA genes. The fusion of the SPOP and RARA genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SPOP-RARA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SPOP-RARA-20-RERE | 20 (40 μL) | 200 μL |
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| SPOP-RARA-20-REOR | 20 (40 μL) | 200 μL |
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| SPOP-RARA-20-REGO | 20 (40 μL) | 200 μL |
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| SPOP-RARA-20-REGR | 20 (40 μL) | 200 μL |
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| SPOP-RARA-20-REAQ | 20 (40 μL) | 200 μL |
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| SPOP-RARA-20-ORRE | 20 (40 μL) | 200 μL |
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| SPOP-RARA-20-OROR | 20 (40 μL) | 200 μL |
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| SPOP-RARA-20-ORGO | 20 (40 μL) | 200 μL |
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| SPOP-RARA-20-ORAQ | 20 (40 μL) | 200 μL |
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| SPOP-RARA-20-GORE | 20 (40 μL) | 200 μL |
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| SPOP-RARA-20-GOOR | 20 (40 μL) | 200 μL |
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| SPOP-RARA-20-GOGO | 20 (40 μL) | 200 μL |
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| SPOP-RARA-20-GOGR | 20 (40 μL) | 200 μL |
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| SPOP-RARA-20-GOAQ | 20 (40 μL) | 200 μL |
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| SPOP-RARA-20-GRRE | 20 (40 μL) | 200 μL |
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| SPOP-RARA-20-GROR | 20 (40 μL) | 200 μL |
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| SPOP-RARA-20-GRGO | 20 (40 μL) | 200 μL |
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| SPOP-RARA-20-GRGR | 20 (40 μL) | 200 μL |
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| SPOP-RARA-20-GRAQ | 20 (40 μL) | 200 μL |
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| SPOP-RARA-20-AQRE | 20 (40 μL) | 200 μL |
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| SPOP-RARA-20-AQOR | 20 (40 μL) | 200 μL |
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| SPOP-RARA-20-AQGO | 20 (40 μL) | 200 μL |
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| SPOP-RARA-20-AQGR | 20 (40 μL) | 200 μL |
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| SPOP-RARA-20-AQAQ | 20 (40 μL) | 200 μL |
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RARA Gene Summary
This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]
Gene Name: Retinoic Acid Receptor Alpha
Chromosome: CHR17: 38465422 -38513895
Locus: 17q21.2
SPOP Gene Summary
This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Name: Speckle Type BTB/POZ Protein
Chromosome: CHR17: 47676245 -47755525
Locus: 17q21.33
Gene Diseases
The SPOP RARA Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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