SPOP-XYLT2 Fusion FISH Probe
The SPOP-XYLT2 Fusion FISH Probe is used to confirm a fusion of the SPOP and XYLT2 genes. The fusion of the SPOP and XYLT2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SPOP-XYLT2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SPOP-XYLT2-20-RERE | 20 (40 μL) | 200 μL |
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| SPOP-XYLT2-20-REOR | 20 (40 μL) | 200 μL |
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| SPOP-XYLT2-20-REGO | 20 (40 μL) | 200 μL |
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| SPOP-XYLT2-20-REGR | 20 (40 μL) | 200 μL |
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| SPOP-XYLT2-20-REAQ | 20 (40 μL) | 200 μL |
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| SPOP-XYLT2-20-ORRE | 20 (40 μL) | 200 μL |
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| SPOP-XYLT2-20-OROR | 20 (40 μL) | 200 μL |
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| SPOP-XYLT2-20-ORGO | 20 (40 μL) | 200 μL |
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| SPOP-XYLT2-20-ORAQ | 20 (40 μL) | 200 μL |
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| SPOP-XYLT2-20-GORE | 20 (40 μL) | 200 μL |
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| SPOP-XYLT2-20-GOOR | 20 (40 μL) | 200 μL |
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| SPOP-XYLT2-20-GOGO | 20 (40 μL) | 200 μL |
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| SPOP-XYLT2-20-GOGR | 20 (40 μL) | 200 μL |
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| SPOP-XYLT2-20-GOAQ | 20 (40 μL) | 200 μL |
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| SPOP-XYLT2-20-GRRE | 20 (40 μL) | 200 μL |
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| SPOP-XYLT2-20-GROR | 20 (40 μL) | 200 μL |
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| SPOP-XYLT2-20-GRGO | 20 (40 μL) | 200 μL |
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| SPOP-XYLT2-20-GRGR | 20 (40 μL) | 200 μL |
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| SPOP-XYLT2-20-GRAQ | 20 (40 μL) | 200 μL |
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| SPOP-XYLT2-20-AQRE | 20 (40 μL) | 200 μL |
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| SPOP-XYLT2-20-AQOR | 20 (40 μL) | 200 μL |
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| SPOP-XYLT2-20-AQGO | 20 (40 μL) | 200 μL |
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| SPOP-XYLT2-20-AQGR | 20 (40 μL) | 200 μL |
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| SPOP-XYLT2-20-AQAQ | 20 (40 μL) | 200 μL |
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SPOP Gene Summary
This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Name: Speckle Type BTB/POZ Protein
Chromosome: CHR17: 47676245 -47755525
Locus: 17q21.33
XYLT2 Gene Summary
The protein encoded by this gene is an isoform of xylosyltransferase, which belongs to a family of glycosyltransferases. This enzyme transfers xylose from UDP-xylose to specific serine residues of the core protein and initiates the biosynthesis of glycosaminoglycan chains in proteoglycans including chondroitin sulfate, heparan sulfate, heparin and dermatan sulfate. The enzyme activity, which is increased in scleroderma patients, is a diagnostic marker for the determination of sclerotic activity in systemic sclerosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
Gene Name: Xylosyltransferase 2
Chromosome: CHR17: 48423392 -48438512
Locus: 17q21.33
Gene Diseases
The SPOP XYLT2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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