SPP1-STAT6 Fusion FISH Probe
The SPP1-STAT6 Fusion FISH Probe is used to confirm a fusion of the SPP1 and STAT6 genes. The fusion of the SPP1 and STAT6 genes has been associated with Kidney Chromophobe. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SPP1-STAT6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SPP1-STAT6-20-RERE | 20 (40 μL) | 200 μL |
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| SPP1-STAT6-20-REOR | 20 (40 μL) | 200 μL |
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| SPP1-STAT6-20-REGO | 20 (40 μL) | 200 μL |
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| SPP1-STAT6-20-REGR | 20 (40 μL) | 200 μL |
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| SPP1-STAT6-20-REAQ | 20 (40 μL) | 200 μL |
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| SPP1-STAT6-20-ORRE | 20 (40 μL) | 200 μL |
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| SPP1-STAT6-20-OROR | 20 (40 μL) | 200 μL |
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| SPP1-STAT6-20-ORGO | 20 (40 μL) | 200 μL |
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| SPP1-STAT6-20-ORAQ | 20 (40 μL) | 200 μL |
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| SPP1-STAT6-20-GORE | 20 (40 μL) | 200 μL |
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| SPP1-STAT6-20-GOOR | 20 (40 μL) | 200 μL |
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| SPP1-STAT6-20-GOGO | 20 (40 μL) | 200 μL |
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| SPP1-STAT6-20-GOGR | 20 (40 μL) | 200 μL |
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| SPP1-STAT6-20-GOAQ | 20 (40 μL) | 200 μL |
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| SPP1-STAT6-20-GRRE | 20 (40 μL) | 200 μL |
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| SPP1-STAT6-20-GROR | 20 (40 μL) | 200 μL |
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| SPP1-STAT6-20-GRGO | 20 (40 μL) | 200 μL |
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| SPP1-STAT6-20-GRGR | 20 (40 μL) | 200 μL |
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| SPP1-STAT6-20-GRAQ | 20 (40 μL) | 200 μL |
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| SPP1-STAT6-20-AQRE | 20 (40 μL) | 200 μL |
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| SPP1-STAT6-20-AQOR | 20 (40 μL) | 200 μL |
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| SPP1-STAT6-20-AQGO | 20 (40 μL) | 200 μL |
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| SPP1-STAT6-20-AQGR | 20 (40 μL) | 200 μL |
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| SPP1-STAT6-20-AQAQ | 20 (40 μL) | 200 μL |
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SPP1 Gene Summary
The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Secreted Phosphoprotein 1
Chromosome: CHR4: 88896801 -88904563
Locus: 4q22.1
STAT6 Gene Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Name: Signal Transducer And Activator Of Transcription 6
Chromosome: CHR12: 57489186 -57505196
Locus: 12q13.3
Gene Diseases
The SPP1 STAT6 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Chromophobe |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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