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SPP1-TYK2 Fusion FISH Probe

The SPP1-TYK2 Fusion FISH Probe is used to confirm a fusion of the SPP1 and TYK2 genes. The fusion of the SPP1 and TYK2 genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
SPP1-TYK2-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
SPP1-TYK2-20-RERE 20 (40 μL) 200 μL
SPP1-TYK2-20-REOR 20 (40 μL) 200 μL
SPP1-TYK2-20-REGO 20 (40 μL) 200 μL
SPP1-TYK2-20-REGR 20 (40 μL) 200 μL
SPP1-TYK2-20-REAQ 20 (40 μL) 200 μL
SPP1-TYK2-20-ORRE 20 (40 μL) 200 μL
SPP1-TYK2-20-OROR 20 (40 μL) 200 μL
SPP1-TYK2-20-ORGO 20 (40 μL) 200 μL
SPP1-TYK2-20-ORAQ 20 (40 μL) 200 μL
SPP1-TYK2-20-GORE 20 (40 μL) 200 μL
SPP1-TYK2-20-GOOR 20 (40 μL) 200 μL
SPP1-TYK2-20-GOGO 20 (40 μL) 200 μL
SPP1-TYK2-20-GOGR 20 (40 μL) 200 μL
SPP1-TYK2-20-GOAQ 20 (40 μL) 200 μL
SPP1-TYK2-20-GRRE 20 (40 μL) 200 μL
SPP1-TYK2-20-GROR 20 (40 μL) 200 μL
SPP1-TYK2-20-GRGO 20 (40 μL) 200 μL
SPP1-TYK2-20-GRGR 20 (40 μL) 200 μL
SPP1-TYK2-20-GRAQ 20 (40 μL) 200 μL
SPP1-TYK2-20-AQRE 20 (40 μL) 200 μL
SPP1-TYK2-20-AQOR 20 (40 μL) 200 μL
SPP1-TYK2-20-AQGO 20 (40 μL) 200 μL
SPP1-TYK2-20-AQGR 20 (40 μL) 200 μL
SPP1-TYK2-20-AQAQ 20 (40 μL) 200 μL

SPP1 Gene Summary

The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Gene Name: Secreted Phosphoprotein 1

Chromosome: CHR4: 88896801 -88904563

Locus: 4q22.1

TYK2 Gene Summary

This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]

Gene Name: Tyrosine Kinase 2

Chromosome: CHR19: 10461203 -10491248

Locus: 19p13.2

Gene Diseases

The SPP1 TYK2 Fusion has been associated with the following diseases:

Disease Name
Kidney Renal Clear Cell Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.