SPRED1-AP3B2 Fusion FISH Probe
The SPRED1-AP3B2 Fusion FISH Probe is used to confirm a fusion of the SPRED1 and AP3B2 genes. The fusion of the SPRED1 and AP3B2 genes has been associated with Rectum Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SPRED1-AP3B2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SPRED1-AP3B2-20-RERE | 20 (40 μL) | 200 μL |
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| SPRED1-AP3B2-20-REOR | 20 (40 μL) | 200 μL |
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| SPRED1-AP3B2-20-REGO | 20 (40 μL) | 200 μL |
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| SPRED1-AP3B2-20-REGR | 20 (40 μL) | 200 μL |
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| SPRED1-AP3B2-20-REAQ | 20 (40 μL) | 200 μL |
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| SPRED1-AP3B2-20-ORRE | 20 (40 μL) | 200 μL |
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| SPRED1-AP3B2-20-OROR | 20 (40 μL) | 200 μL |
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| SPRED1-AP3B2-20-ORGO | 20 (40 μL) | 200 μL |
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| SPRED1-AP3B2-20-ORAQ | 20 (40 μL) | 200 μL |
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| SPRED1-AP3B2-20-GORE | 20 (40 μL) | 200 μL |
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| SPRED1-AP3B2-20-GOOR | 20 (40 μL) | 200 μL |
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| SPRED1-AP3B2-20-GOGO | 20 (40 μL) | 200 μL |
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| SPRED1-AP3B2-20-GOGR | 20 (40 μL) | 200 μL |
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| SPRED1-AP3B2-20-GOAQ | 20 (40 μL) | 200 μL |
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| SPRED1-AP3B2-20-GRRE | 20 (40 μL) | 200 μL |
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| SPRED1-AP3B2-20-GROR | 20 (40 μL) | 200 μL |
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| SPRED1-AP3B2-20-GRGO | 20 (40 μL) | 200 μL |
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| SPRED1-AP3B2-20-GRGR | 20 (40 μL) | 200 μL |
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| SPRED1-AP3B2-20-GRAQ | 20 (40 μL) | 200 μL |
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| SPRED1-AP3B2-20-AQRE | 20 (40 μL) | 200 μL |
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| SPRED1-AP3B2-20-AQOR | 20 (40 μL) | 200 μL |
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| SPRED1-AP3B2-20-AQGO | 20 (40 μL) | 200 μL |
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| SPRED1-AP3B2-20-AQGR | 20 (40 μL) | 200 μL |
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| SPRED1-AP3B2-20-AQAQ | 20 (40 μL) | 200 μL |
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AP3B2 Gene Summary
Adaptor protein complex 3 (AP-3 complex) is a heterotrimeric protein complex involved in the formation of clathrin-coated synaptic vesicles. The protein encoded by this gene represents the beta subunit of the neuron-specific AP-3 complex and was first identified as the target antigen in human paraneoplastic neurologic disorders. The encoded subunit binds clathrin and is phosphorylated by a casein kinase-like protein, which mediates synaptic vesicle coat assembly. Defects in this gene are a cause of early-onset epileptic encephalopathy. [provided by RefSeq, Feb 2017]
Gene Name: Adaptor Related Protein Complex 3 Beta 2 Subunit
Chromosome: CHR15: 83328032 -83378635
Locus: 15q25.2
SPRED1 Gene Summary
The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008]
Gene Name: Sprouty Related EVH1 Domain Containing 1
Chromosome: CHR15: 38545051 -38649450
Locus: 15q14
Gene Diseases
The SPRED1 AP3B2 Fusion has been associated with the following diseases:
| Disease Name |
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| Rectum Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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