SPSB1-TAF12 Fusion FISH Probe
The SPSB1-TAF12 Fusion FISH Probe is used to confirm a fusion of the SPSB1 and TAF12 genes. The fusion of the SPSB1 and TAF12 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SPSB1-TAF12-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SPSB1-TAF12-20-RERE | 20 (40 μL) | 200 μL |
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| SPSB1-TAF12-20-REOR | 20 (40 μL) | 200 μL |
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| SPSB1-TAF12-20-REGO | 20 (40 μL) | 200 μL |
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| SPSB1-TAF12-20-REGR | 20 (40 μL) | 200 μL |
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| SPSB1-TAF12-20-REAQ | 20 (40 μL) | 200 μL |
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| SPSB1-TAF12-20-ORRE | 20 (40 μL) | 200 μL |
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| SPSB1-TAF12-20-OROR | 20 (40 μL) | 200 μL |
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| SPSB1-TAF12-20-ORGO | 20 (40 μL) | 200 μL |
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| SPSB1-TAF12-20-ORAQ | 20 (40 μL) | 200 μL |
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| SPSB1-TAF12-20-GORE | 20 (40 μL) | 200 μL |
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| SPSB1-TAF12-20-GOOR | 20 (40 μL) | 200 μL |
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| SPSB1-TAF12-20-GOGO | 20 (40 μL) | 200 μL |
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| SPSB1-TAF12-20-GOGR | 20 (40 μL) | 200 μL |
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| SPSB1-TAF12-20-GOAQ | 20 (40 μL) | 200 μL |
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| SPSB1-TAF12-20-GRRE | 20 (40 μL) | 200 μL |
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| SPSB1-TAF12-20-GROR | 20 (40 μL) | 200 μL |
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| SPSB1-TAF12-20-GRGO | 20 (40 μL) | 200 μL |
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| SPSB1-TAF12-20-GRGR | 20 (40 μL) | 200 μL |
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| SPSB1-TAF12-20-GRAQ | 20 (40 μL) | 200 μL |
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| SPSB1-TAF12-20-AQRE | 20 (40 μL) | 200 μL |
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| SPSB1-TAF12-20-AQOR | 20 (40 μL) | 200 μL |
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| SPSB1-TAF12-20-AQGO | 20 (40 μL) | 200 μL |
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| SPSB1-TAF12-20-AQGR | 20 (40 μL) | 200 μL |
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| SPSB1-TAF12-20-AQAQ | 20 (40 μL) | 200 μL |
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TAF12 Gene Summary
Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Name: TATA-box Binding Protein Associated Factor 12
Chromosome: CHR1: 28929608 -28969604
Locus: 1p35.3
SPSB1 Gene Summary
The SplA/ryanodine Receptor Domain And SOCS Box Containing 1 (SPSB1) gene is located on chr1 :9352940-9429590 at 1p36.22.
Gene Name: SplA/ryanodine Receptor Domain And SOCS Box Containing 1
Chromosome: CHR1: 9352940 -9429590
Locus: 1p36.22
Gene Diseases
The SPSB1 TAF12 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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