SPTLC2-SNW1 Fusion FISH Probe
The SPTLC2-SNW1 Fusion FISH Probe is used to confirm a fusion of the SPTLC2 and SNW1 genes. The fusion of the SPTLC2 and SNW1 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SPTLC2-SNW1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SPTLC2-SNW1-20-RERE | 20 (40 μL) | 200 μL |
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| SPTLC2-SNW1-20-REOR | 20 (40 μL) | 200 μL |
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| SPTLC2-SNW1-20-REGO | 20 (40 μL) | 200 μL |
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| SPTLC2-SNW1-20-REGR | 20 (40 μL) | 200 μL |
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| SPTLC2-SNW1-20-REAQ | 20 (40 μL) | 200 μL |
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| SPTLC2-SNW1-20-ORRE | 20 (40 μL) | 200 μL |
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| SPTLC2-SNW1-20-OROR | 20 (40 μL) | 200 μL |
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| SPTLC2-SNW1-20-ORGO | 20 (40 μL) | 200 μL |
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| SPTLC2-SNW1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SPTLC2-SNW1-20-GORE | 20 (40 μL) | 200 μL |
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| SPTLC2-SNW1-20-GOOR | 20 (40 μL) | 200 μL |
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| SPTLC2-SNW1-20-GOGO | 20 (40 μL) | 200 μL |
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| SPTLC2-SNW1-20-GOGR | 20 (40 μL) | 200 μL |
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| SPTLC2-SNW1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SPTLC2-SNW1-20-GRRE | 20 (40 μL) | 200 μL |
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| SPTLC2-SNW1-20-GROR | 20 (40 μL) | 200 μL |
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| SPTLC2-SNW1-20-GRGO | 20 (40 μL) | 200 μL |
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| SPTLC2-SNW1-20-GRGR | 20 (40 μL) | 200 μL |
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| SPTLC2-SNW1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SPTLC2-SNW1-20-AQRE | 20 (40 μL) | 200 μL |
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| SPTLC2-SNW1-20-AQOR | 20 (40 μL) | 200 μL |
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| SPTLC2-SNW1-20-AQGO | 20 (40 μL) | 200 μL |
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| SPTLC2-SNW1-20-AQGR | 20 (40 μL) | 200 μL |
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| SPTLC2-SNW1-20-AQAQ | 20 (40 μL) | 200 μL |
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SPTLC2 Gene Summary
This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. [provided by RefSeq, Mar 2011]
Gene Name: Serine Palmitoyltransferase Long Chain Base Subunit 2
Chromosome: CHR14: 77972339 -78083110
Locus: 14q24.3
SNW1 Gene Summary
This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Gene Name: SNW Domain Containing 1
Chromosome: CHR14: 78183943 -78227497
Locus: 14q24.3
Gene Diseases
The SPTLC2 SNW1 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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