SRCAP-RPS4Y1 Fusion FISH Probe
The SRCAP-RPS4Y1 Fusion FISH Probe is used to confirm a fusion of the SRCAP and RPS4Y1 genes. The fusion of the SRCAP and RPS4Y1 genes has been associated with Glioblastoma Multiforme. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SRCAP-RPS4Y1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SRCAP-RPS4Y1-20-RERE | 20 (40 μL) | 200 μL |
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| SRCAP-RPS4Y1-20-REOR | 20 (40 μL) | 200 μL |
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| SRCAP-RPS4Y1-20-REGO | 20 (40 μL) | 200 μL |
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| SRCAP-RPS4Y1-20-REGR | 20 (40 μL) | 200 μL |
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| SRCAP-RPS4Y1-20-REAQ | 20 (40 μL) | 200 μL |
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| SRCAP-RPS4Y1-20-ORRE | 20 (40 μL) | 200 μL |
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| SRCAP-RPS4Y1-20-OROR | 20 (40 μL) | 200 μL |
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| SRCAP-RPS4Y1-20-ORGO | 20 (40 μL) | 200 μL |
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| SRCAP-RPS4Y1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SRCAP-RPS4Y1-20-GORE | 20 (40 μL) | 200 μL |
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| SRCAP-RPS4Y1-20-GOOR | 20 (40 μL) | 200 μL |
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| SRCAP-RPS4Y1-20-GOGO | 20 (40 μL) | 200 μL |
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| SRCAP-RPS4Y1-20-GOGR | 20 (40 μL) | 200 μL |
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| SRCAP-RPS4Y1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SRCAP-RPS4Y1-20-GRRE | 20 (40 μL) | 200 μL |
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| SRCAP-RPS4Y1-20-GROR | 20 (40 μL) | 200 μL |
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| SRCAP-RPS4Y1-20-GRGO | 20 (40 μL) | 200 μL |
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| SRCAP-RPS4Y1-20-GRGR | 20 (40 μL) | 200 μL |
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| SRCAP-RPS4Y1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SRCAP-RPS4Y1-20-AQRE | 20 (40 μL) | 200 μL |
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| SRCAP-RPS4Y1-20-AQOR | 20 (40 μL) | 200 μL |
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| SRCAP-RPS4Y1-20-AQGO | 20 (40 μL) | 200 μL |
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| SRCAP-RPS4Y1-20-AQGR | 20 (40 μL) | 200 μL |
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| SRCAP-RPS4Y1-20-AQAQ | 20 (40 μL) | 200 μL |
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RPS4Y1 Gene Summary
Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein known to be encoded by more than one gene, namely this gene and ribosomal protein S4, X-linked (RPS4X). The 2 isoforms encoded by these genes are not identical, but are functionally equivalent. Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome; however, this hypothesis is controversial. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Gene Name: Ribosomal Protein S4, Y-linked 1
Chromosome: CHRY: 2709622 -2734997
Locus: Yp11.2
SRCAP Gene Summary
This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012]
Gene Name: Snf2 Related CREBBP Activator Protein
Chromosome: CHR16: 30710461 -30751450
Locus: 16p11.2
Gene Diseases
The SRCAP RPS4Y1 Fusion has been associated with the following diseases:
| Disease Name |
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| Glioblastoma Multiforme |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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