SREBF1-MED9 Fusion FISH Probe
The SREBF1-MED9 Fusion FISH Probe is used to confirm a fusion of the SREBF1 and MED9 genes. The fusion of the SREBF1 and MED9 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SREBF1-MED9-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SREBF1-MED9-20-RERE | 20 (40 μL) | 200 μL |
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| SREBF1-MED9-20-REOR | 20 (40 μL) | 200 μL |
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| SREBF1-MED9-20-REGO | 20 (40 μL) | 200 μL |
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| SREBF1-MED9-20-REGR | 20 (40 μL) | 200 μL |
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| SREBF1-MED9-20-REAQ | 20 (40 μL) | 200 μL |
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| SREBF1-MED9-20-ORRE | 20 (40 μL) | 200 μL |
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| SREBF1-MED9-20-OROR | 20 (40 μL) | 200 μL |
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| SREBF1-MED9-20-ORGO | 20 (40 μL) | 200 μL |
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| SREBF1-MED9-20-ORAQ | 20 (40 μL) | 200 μL |
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| SREBF1-MED9-20-GORE | 20 (40 μL) | 200 μL |
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| SREBF1-MED9-20-GOOR | 20 (40 μL) | 200 μL |
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| SREBF1-MED9-20-GOGO | 20 (40 μL) | 200 μL |
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| SREBF1-MED9-20-GOGR | 20 (40 μL) | 200 μL |
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| SREBF1-MED9-20-GOAQ | 20 (40 μL) | 200 μL |
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| SREBF1-MED9-20-GRRE | 20 (40 μL) | 200 μL |
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| SREBF1-MED9-20-GROR | 20 (40 μL) | 200 μL |
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| SREBF1-MED9-20-GRGO | 20 (40 μL) | 200 μL |
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| SREBF1-MED9-20-GRGR | 20 (40 μL) | 200 μL |
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| SREBF1-MED9-20-GRAQ | 20 (40 μL) | 200 μL |
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| SREBF1-MED9-20-AQRE | 20 (40 μL) | 200 μL |
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| SREBF1-MED9-20-AQOR | 20 (40 μL) | 200 μL |
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| SREBF1-MED9-20-AQGO | 20 (40 μL) | 200 μL |
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| SREBF1-MED9-20-AQGR | 20 (40 μL) | 200 μL |
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| SREBF1-MED9-20-AQAQ | 20 (40 μL) | 200 μL |
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SREBF1 Gene Summary
This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative promoter usage and splicing result in multiple transcript variants, including SREBP-1a and SREBP-1c, which correspond to RefSeq transcript variants 2 and 3, respectively. [provided by RefSeq, Nov 2017]
Gene Name: Sterol Regulatory Element Binding Transcription Factor 1
Chromosome: CHR17: 17714662 -17740325
Locus: 17p11.2
MED9 Gene Summary
The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. The protein encoded by this gene is thought to be a subunit of the Mediator complex. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Gene Name: Mediator Complex Subunit 9
Chromosome: CHR17: 17380299 -17396534
Locus: 17p11.2
Gene Diseases
The SREBF1 MED9 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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