SREBF1-STAT3 Fusion FISH Probe
The SREBF1-STAT3 Fusion FISH Probe is used to confirm a fusion of the SREBF1 and STAT3 genes. The fusion of the SREBF1 and STAT3 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SREBF1-STAT3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SREBF1-STAT3-20-RERE | 20 (40 μL) | 200 μL |
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| SREBF1-STAT3-20-REOR | 20 (40 μL) | 200 μL |
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| SREBF1-STAT3-20-REGO | 20 (40 μL) | 200 μL |
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| SREBF1-STAT3-20-REGR | 20 (40 μL) | 200 μL |
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| SREBF1-STAT3-20-REAQ | 20 (40 μL) | 200 μL |
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| SREBF1-STAT3-20-ORRE | 20 (40 μL) | 200 μL |
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| SREBF1-STAT3-20-OROR | 20 (40 μL) | 200 μL |
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| SREBF1-STAT3-20-ORGO | 20 (40 μL) | 200 μL |
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| SREBF1-STAT3-20-ORAQ | 20 (40 μL) | 200 μL |
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| SREBF1-STAT3-20-GORE | 20 (40 μL) | 200 μL |
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| SREBF1-STAT3-20-GOOR | 20 (40 μL) | 200 μL |
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| SREBF1-STAT3-20-GOGO | 20 (40 μL) | 200 μL |
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| SREBF1-STAT3-20-GOGR | 20 (40 μL) | 200 μL |
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| SREBF1-STAT3-20-GOAQ | 20 (40 μL) | 200 μL |
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| SREBF1-STAT3-20-GRRE | 20 (40 μL) | 200 μL |
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| SREBF1-STAT3-20-GROR | 20 (40 μL) | 200 μL |
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| SREBF1-STAT3-20-GRGO | 20 (40 μL) | 200 μL |
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| SREBF1-STAT3-20-GRGR | 20 (40 μL) | 200 μL |
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| SREBF1-STAT3-20-GRAQ | 20 (40 μL) | 200 μL |
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| SREBF1-STAT3-20-AQRE | 20 (40 μL) | 200 μL |
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| SREBF1-STAT3-20-AQOR | 20 (40 μL) | 200 μL |
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| SREBF1-STAT3-20-AQGO | 20 (40 μL) | 200 μL |
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| SREBF1-STAT3-20-AQGR | 20 (40 μL) | 200 μL |
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| SREBF1-STAT3-20-AQAQ | 20 (40 μL) | 200 μL |
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SREBF1 Gene Summary
This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative promoter usage and splicing result in multiple transcript variants, including SREBP-1a and SREBP-1c, which correspond to RefSeq transcript variants 2 and 3, respectively. [provided by RefSeq, Nov 2017]
Gene Name: Sterol Regulatory Element Binding Transcription Factor 1
Chromosome: CHR17: 17714662 -17740325
Locus: 17p11.2
STAT3 Gene Summary
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]
Gene Name: Signal Transducer And Activator Of Transcription 3
Chromosome: CHR17: 40465342 -40540513
Locus: 17q21.2
Gene Diseases
The SREBF1 STAT3 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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