SREBF2-ACO2 Fusion FISH Probe
The SREBF2-ACO2 Fusion FISH Probe is used to confirm a fusion of the SREBF2 and ACO2 genes. The fusion of the SREBF2 and ACO2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SREBF2-ACO2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SREBF2-ACO2-20-RERE | 20 (40 μL) | 200 μL |
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| SREBF2-ACO2-20-REOR | 20 (40 μL) | 200 μL |
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| SREBF2-ACO2-20-REGO | 20 (40 μL) | 200 μL |
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| SREBF2-ACO2-20-REGR | 20 (40 μL) | 200 μL |
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| SREBF2-ACO2-20-REAQ | 20 (40 μL) | 200 μL |
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| SREBF2-ACO2-20-ORRE | 20 (40 μL) | 200 μL |
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| SREBF2-ACO2-20-OROR | 20 (40 μL) | 200 μL |
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| SREBF2-ACO2-20-ORGO | 20 (40 μL) | 200 μL |
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| SREBF2-ACO2-20-ORAQ | 20 (40 μL) | 200 μL |
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| SREBF2-ACO2-20-GORE | 20 (40 μL) | 200 μL |
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| SREBF2-ACO2-20-GOOR | 20 (40 μL) | 200 μL |
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| SREBF2-ACO2-20-GOGO | 20 (40 μL) | 200 μL |
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| SREBF2-ACO2-20-GOGR | 20 (40 μL) | 200 μL |
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| SREBF2-ACO2-20-GOAQ | 20 (40 μL) | 200 μL |
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| SREBF2-ACO2-20-GRRE | 20 (40 μL) | 200 μL |
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| SREBF2-ACO2-20-GROR | 20 (40 μL) | 200 μL |
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| SREBF2-ACO2-20-GRGO | 20 (40 μL) | 200 μL |
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| SREBF2-ACO2-20-GRGR | 20 (40 μL) | 200 μL |
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| SREBF2-ACO2-20-GRAQ | 20 (40 μL) | 200 μL |
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| SREBF2-ACO2-20-AQRE | 20 (40 μL) | 200 μL |
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| SREBF2-ACO2-20-AQOR | 20 (40 μL) | 200 μL |
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| SREBF2-ACO2-20-AQGO | 20 (40 μL) | 200 μL |
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| SREBF2-ACO2-20-AQGR | 20 (40 μL) | 200 μL |
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| SREBF2-ACO2-20-AQAQ | 20 (40 μL) | 200 μL |
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ACO2 Gene Summary
The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 2008]
Gene Name: Aconitase 2
Chromosome: CHR22: 41865128 -41924993
Locus: 22q13.2
SREBF2 Gene Summary
This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Name: Sterol Regulatory Element Binding Transcription Factor 2
Chromosome: CHR22: 42229105 -42302375
Locus: 22q13.2
Gene Diseases
The SREBF2 ACO2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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