SRF-F5 Fusion FISH Probe
The SRF-F5 Fusion FISH Probe is used to confirm a fusion of the SRF and F5 genes. The fusion of the SRF and F5 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SRF-F5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SRF-F5-20-RERE | 20 (40 μL) | 200 μL |
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| SRF-F5-20-REOR | 20 (40 μL) | 200 μL |
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| SRF-F5-20-REGO | 20 (40 μL) | 200 μL |
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| SRF-F5-20-REGR | 20 (40 μL) | 200 μL |
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| SRF-F5-20-REAQ | 20 (40 μL) | 200 μL |
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| SRF-F5-20-ORRE | 20 (40 μL) | 200 μL |
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| SRF-F5-20-OROR | 20 (40 μL) | 200 μL |
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| SRF-F5-20-ORGO | 20 (40 μL) | 200 μL |
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| SRF-F5-20-ORAQ | 20 (40 μL) | 200 μL |
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| SRF-F5-20-GORE | 20 (40 μL) | 200 μL |
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| SRF-F5-20-GOOR | 20 (40 μL) | 200 μL |
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| SRF-F5-20-GOGO | 20 (40 μL) | 200 μL |
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| SRF-F5-20-GOGR | 20 (40 μL) | 200 μL |
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| SRF-F5-20-GOAQ | 20 (40 μL) | 200 μL |
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| SRF-F5-20-GRRE | 20 (40 μL) | 200 μL |
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| SRF-F5-20-GROR | 20 (40 μL) | 200 μL |
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| SRF-F5-20-GRGO | 20 (40 μL) | 200 μL |
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| SRF-F5-20-GRGR | 20 (40 μL) | 200 μL |
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| SRF-F5-20-GRAQ | 20 (40 μL) | 200 μL |
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| SRF-F5-20-AQRE | 20 (40 μL) | 200 μL |
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| SRF-F5-20-AQOR | 20 (40 μL) | 200 μL |
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| SRF-F5-20-AQGO | 20 (40 μL) | 200 μL |
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| SRF-F5-20-AQGR | 20 (40 μL) | 200 μL |
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| SRF-F5-20-AQAQ | 20 (40 μL) | 200 μL |
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F5 Gene Summary
This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. [provided by RefSeq, Oct 2008]
Gene Name: Coagulation Factor V
Chromosome: CHR1: 169481191 -169555769
Locus: 1q24.2
SRF Gene Summary
This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
Gene Name: Serum Response Factor
Chromosome: CHR6: 43138919 -43149244
Locus: 6p21.1
Gene Diseases
The SRF F5 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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