STC2-TYK2 Fusion FISH Probe
The STC2-TYK2 Fusion FISH Probe is used to confirm a fusion of the STC2 and TYK2 genes. The fusion of the STC2 and TYK2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| STC2-TYK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| STC2-TYK2-20-RERE | 20 (40 μL) | 200 μL |
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| STC2-TYK2-20-REOR | 20 (40 μL) | 200 μL |
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| STC2-TYK2-20-REGO | 20 (40 μL) | 200 μL |
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| STC2-TYK2-20-REGR | 20 (40 μL) | 200 μL |
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| STC2-TYK2-20-REAQ | 20 (40 μL) | 200 μL |
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| STC2-TYK2-20-ORRE | 20 (40 μL) | 200 μL |
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| STC2-TYK2-20-OROR | 20 (40 μL) | 200 μL |
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| STC2-TYK2-20-ORGO | 20 (40 μL) | 200 μL |
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| STC2-TYK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| STC2-TYK2-20-GORE | 20 (40 μL) | 200 μL |
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| STC2-TYK2-20-GOOR | 20 (40 μL) | 200 μL |
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| STC2-TYK2-20-GOGO | 20 (40 μL) | 200 μL |
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| STC2-TYK2-20-GOGR | 20 (40 μL) | 200 μL |
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| STC2-TYK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| STC2-TYK2-20-GRRE | 20 (40 μL) | 200 μL |
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| STC2-TYK2-20-GROR | 20 (40 μL) | 200 μL |
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| STC2-TYK2-20-GRGO | 20 (40 μL) | 200 μL |
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| STC2-TYK2-20-GRGR | 20 (40 μL) | 200 μL |
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| STC2-TYK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| STC2-TYK2-20-AQRE | 20 (40 μL) | 200 μL |
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| STC2-TYK2-20-AQOR | 20 (40 μL) | 200 μL |
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| STC2-TYK2-20-AQGO | 20 (40 μL) | 200 μL |
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| STC2-TYK2-20-AQGR | 20 (40 μL) | 200 μL |
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| STC2-TYK2-20-AQAQ | 20 (40 μL) | 200 μL |
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TYK2 Gene Summary
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
Gene Name: Tyrosine Kinase 2
Chromosome: CHR19: 10461203 -10491248
Locus: 19p13.2
STC2 Gene Summary
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. [provided by RefSeq, Jul 2008]
Gene Name: Stanniocalcin 2
Chromosome: CHR5: 172741725 -172756506
Locus: 5q35.2
Gene Diseases
The STC2 TYK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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