STIM1-NUP98 Fusion FISH Probe
The STIM1-NUP98 Fusion FISH Probe is used to confirm a fusion of the STIM1 and NUP98 genes. The fusion of the STIM1 and NUP98 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| STIM1-NUP98-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| STIM1-NUP98-20-RERE | 20 (40 μL) | 200 μL |
|
|
| STIM1-NUP98-20-REOR | 20 (40 μL) | 200 μL |
|
|
| STIM1-NUP98-20-REGO | 20 (40 μL) | 200 μL |
|
|
| STIM1-NUP98-20-REGR | 20 (40 μL) | 200 μL |
|
|
| STIM1-NUP98-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| STIM1-NUP98-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| STIM1-NUP98-20-OROR | 20 (40 μL) | 200 μL |
|
|
| STIM1-NUP98-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| STIM1-NUP98-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| STIM1-NUP98-20-GORE | 20 (40 μL) | 200 μL |
|
|
| STIM1-NUP98-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| STIM1-NUP98-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| STIM1-NUP98-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| STIM1-NUP98-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| STIM1-NUP98-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| STIM1-NUP98-20-GROR | 20 (40 μL) | 200 μL |
|
|
| STIM1-NUP98-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| STIM1-NUP98-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| STIM1-NUP98-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| STIM1-NUP98-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| STIM1-NUP98-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| STIM1-NUP98-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| STIM1-NUP98-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| STIM1-NUP98-20-AQAQ | 20 (40 μL) | 200 μL |
|
NUP98 Gene Summary
Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. [provided by RefSeq, Feb 2016]
Gene Name: Nucleoporin 98
Chromosome: CHR11: 3696239 -3819022
Locus: 11p15.4
STIM1 Gene Summary
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
Gene Name: Stromal Interaction Molecule 1
Chromosome: CHR11: 3876932 -4114440
Locus: 11p15.4
Gene Diseases
The STIM1 NUP98 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|