STIP1-PC Fusion FISH Probe
The STIP1-PC Fusion FISH Probe is used to confirm a fusion of the STIP1 and PC genes. The fusion of the STIP1 and PC genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| STIP1-PC-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| STIP1-PC-20-RERE | 20 (40 μL) | 200 μL |
|
|
| STIP1-PC-20-REOR | 20 (40 μL) | 200 μL |
|
|
| STIP1-PC-20-REGO | 20 (40 μL) | 200 μL |
|
|
| STIP1-PC-20-REGR | 20 (40 μL) | 200 μL |
|
|
| STIP1-PC-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| STIP1-PC-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| STIP1-PC-20-OROR | 20 (40 μL) | 200 μL |
|
|
| STIP1-PC-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| STIP1-PC-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| STIP1-PC-20-GORE | 20 (40 μL) | 200 μL |
|
|
| STIP1-PC-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| STIP1-PC-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| STIP1-PC-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| STIP1-PC-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| STIP1-PC-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| STIP1-PC-20-GROR | 20 (40 μL) | 200 μL |
|
|
| STIP1-PC-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| STIP1-PC-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| STIP1-PC-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| STIP1-PC-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| STIP1-PC-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| STIP1-PC-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| STIP1-PC-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| STIP1-PC-20-AQAQ | 20 (40 μL) | 200 μL |
|
PC Gene Summary
This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Pyruvate Carboxylase
Chromosome: CHR11: 66615996 -66725847
Locus: 11q13.2
STIP1 Gene Summary
STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]
Gene Name: Stress Induced Phosphoprotein 1
Chromosome: CHR11: 63953586 -63972020
Locus: 11q13.1
Gene Diseases
The STIP1 PC Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|