STK3-COX6C Fusion FISH Probe
The STK3-COX6C Fusion FISH Probe is used to confirm a fusion of the STK3 and COX6C genes. The fusion of the STK3 and COX6C genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| STK3-COX6C-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| STK3-COX6C-20-RERE | 20 (40 μL) | 200 μL |
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| STK3-COX6C-20-REOR | 20 (40 μL) | 200 μL |
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| STK3-COX6C-20-REGO | 20 (40 μL) | 200 μL |
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| STK3-COX6C-20-REGR | 20 (40 μL) | 200 μL |
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| STK3-COX6C-20-REAQ | 20 (40 μL) | 200 μL |
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| STK3-COX6C-20-ORRE | 20 (40 μL) | 200 μL |
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| STK3-COX6C-20-OROR | 20 (40 μL) | 200 μL |
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| STK3-COX6C-20-ORGO | 20 (40 μL) | 200 μL |
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| STK3-COX6C-20-ORAQ | 20 (40 μL) | 200 μL |
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| STK3-COX6C-20-GORE | 20 (40 μL) | 200 μL |
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| STK3-COX6C-20-GOOR | 20 (40 μL) | 200 μL |
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| STK3-COX6C-20-GOGO | 20 (40 μL) | 200 μL |
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| STK3-COX6C-20-GOGR | 20 (40 μL) | 200 μL |
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| STK3-COX6C-20-GOAQ | 20 (40 μL) | 200 μL |
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| STK3-COX6C-20-GRRE | 20 (40 μL) | 200 μL |
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| STK3-COX6C-20-GROR | 20 (40 μL) | 200 μL |
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| STK3-COX6C-20-GRGO | 20 (40 μL) | 200 μL |
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| STK3-COX6C-20-GRGR | 20 (40 μL) | 200 μL |
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| STK3-COX6C-20-GRAQ | 20 (40 μL) | 200 μL |
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| STK3-COX6C-20-AQRE | 20 (40 μL) | 200 μL |
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| STK3-COX6C-20-AQOR | 20 (40 μL) | 200 μL |
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| STK3-COX6C-20-AQGO | 20 (40 μL) | 200 μL |
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| STK3-COX6C-20-AQGR | 20 (40 μL) | 200 μL |
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| STK3-COX6C-20-AQAQ | 20 (40 μL) | 200 μL |
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COX6C Gene Summary
Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes 16p12. [provided by RefSeq, Jul 2010]
Gene Name: Cytochrome C Oxidase Subunit 6C
Chromosome: CHR8: 100890222 -100906242
Locus: 8q22.2
STK3 Gene Summary
This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Name: Serine/threonine Kinase 3
Chromosome: CHR8: 99466860 -99837909
Locus: 8q22.2
Gene Diseases
The STK3 COX6C Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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