STK35-GP5 Fusion FISH Probe
The STK35-GP5 Fusion FISH Probe is used to confirm a fusion of the STK35 and GP5 genes. The fusion of the STK35 and GP5 genes has been associated with Liver Hepatocellular Carcinoma, and Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| STK35-GP5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| STK35-GP5-20-RERE | 20 (40 μL) | 200 μL |
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| STK35-GP5-20-REOR | 20 (40 μL) | 200 μL |
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| STK35-GP5-20-REGO | 20 (40 μL) | 200 μL |
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| STK35-GP5-20-REGR | 20 (40 μL) | 200 μL |
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| STK35-GP5-20-REAQ | 20 (40 μL) | 200 μL |
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| STK35-GP5-20-ORRE | 20 (40 μL) | 200 μL |
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| STK35-GP5-20-OROR | 20 (40 μL) | 200 μL |
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| STK35-GP5-20-ORGO | 20 (40 μL) | 200 μL |
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| STK35-GP5-20-ORAQ | 20 (40 μL) | 200 μL |
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| STK35-GP5-20-GORE | 20 (40 μL) | 200 μL |
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| STK35-GP5-20-GOOR | 20 (40 μL) | 200 μL |
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| STK35-GP5-20-GOGO | 20 (40 μL) | 200 μL |
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| STK35-GP5-20-GOGR | 20 (40 μL) | 200 μL |
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| STK35-GP5-20-GOAQ | 20 (40 μL) | 200 μL |
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| STK35-GP5-20-GRRE | 20 (40 μL) | 200 μL |
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| STK35-GP5-20-GROR | 20 (40 μL) | 200 μL |
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| STK35-GP5-20-GRGO | 20 (40 μL) | 200 μL |
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| STK35-GP5-20-GRGR | 20 (40 μL) | 200 μL |
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| STK35-GP5-20-GRAQ | 20 (40 μL) | 200 μL |
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| STK35-GP5-20-AQRE | 20 (40 μL) | 200 μL |
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| STK35-GP5-20-AQOR | 20 (40 μL) | 200 μL |
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| STK35-GP5-20-AQGO | 20 (40 μL) | 200 μL |
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| STK35-GP5-20-AQGR | 20 (40 μL) | 200 μL |
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| STK35-GP5-20-AQAQ | 20 (40 μL) | 200 μL |
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GP5 Gene Summary
Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 [PubMed 9616133]).[supplied by OMIM, Nov 2010]
Gene Name: Glycoprotein V Platelet
Chromosome: CHR3: 194115549 -194119995
Locus: 3q29
STK35 Gene Summary
The protein encoded by this gene is a kinase that is predominantly found in the nucleus. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. The encoded protein may be a regulator of actin stress fibers in nonmuscle cells. [provided by RefSeq, Jul 2008]
Gene Name: Serine/threonine Kinase 35
Chromosome: CHR20: 2082527 -2129198
Locus: 20p13
Gene Diseases
The STK35 GP5 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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