STK38-GMDS Fusion FISH Probe
The STK38-GMDS Fusion FISH Probe is used to confirm a fusion of the STK38 and GMDS genes. The fusion of the STK38 and GMDS genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| STK38-GMDS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| STK38-GMDS-20-RERE | 20 (40 μL) | 200 μL |
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| STK38-GMDS-20-REOR | 20 (40 μL) | 200 μL |
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| STK38-GMDS-20-REGO | 20 (40 μL) | 200 μL |
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| STK38-GMDS-20-REGR | 20 (40 μL) | 200 μL |
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| STK38-GMDS-20-REAQ | 20 (40 μL) | 200 μL |
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| STK38-GMDS-20-ORRE | 20 (40 μL) | 200 μL |
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| STK38-GMDS-20-OROR | 20 (40 μL) | 200 μL |
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| STK38-GMDS-20-ORGO | 20 (40 μL) | 200 μL |
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| STK38-GMDS-20-ORAQ | 20 (40 μL) | 200 μL |
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| STK38-GMDS-20-GORE | 20 (40 μL) | 200 μL |
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| STK38-GMDS-20-GOOR | 20 (40 μL) | 200 μL |
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| STK38-GMDS-20-GOGO | 20 (40 μL) | 200 μL |
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| STK38-GMDS-20-GOGR | 20 (40 μL) | 200 μL |
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| STK38-GMDS-20-GOAQ | 20 (40 μL) | 200 μL |
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| STK38-GMDS-20-GRRE | 20 (40 μL) | 200 μL |
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| STK38-GMDS-20-GROR | 20 (40 μL) | 200 μL |
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| STK38-GMDS-20-GRGO | 20 (40 μL) | 200 μL |
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| STK38-GMDS-20-GRGR | 20 (40 μL) | 200 μL |
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| STK38-GMDS-20-GRAQ | 20 (40 μL) | 200 μL |
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| STK38-GMDS-20-AQRE | 20 (40 μL) | 200 μL |
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| STK38-GMDS-20-AQOR | 20 (40 μL) | 200 μL |
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| STK38-GMDS-20-AQGO | 20 (40 μL) | 200 μL |
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| STK38-GMDS-20-AQGR | 20 (40 μL) | 200 μL |
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| STK38-GMDS-20-AQAQ | 20 (40 μL) | 200 μL |
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GMDS Gene Summary
GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009]
Gene Name: GDP-mannose 4,6-dehydratase
Chromosome: CHR6: 1624040 -2245846
Locus: 6p25.3
STK38 Gene Summary
This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Gene Name: Serine/threonine Kinase 38
Chromosome: CHR6: 36461668 -36515247
Locus: 6p21.31
Gene Diseases
The STK38 GMDS Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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