STK39-SCN7A Fusion FISH Probe
The STK39-SCN7A Fusion FISH Probe is used to confirm a fusion of the STK39 and SCN7A genes. The fusion of the STK39 and SCN7A genes has been associated with Mesothelioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| STK39-SCN7A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| STK39-SCN7A-20-RERE | 20 (40 μL) | 200 μL |
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| STK39-SCN7A-20-REOR | 20 (40 μL) | 200 μL |
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| STK39-SCN7A-20-REGO | 20 (40 μL) | 200 μL |
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| STK39-SCN7A-20-REGR | 20 (40 μL) | 200 μL |
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| STK39-SCN7A-20-REAQ | 20 (40 μL) | 200 μL |
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| STK39-SCN7A-20-ORRE | 20 (40 μL) | 200 μL |
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| STK39-SCN7A-20-OROR | 20 (40 μL) | 200 μL |
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| STK39-SCN7A-20-ORGO | 20 (40 μL) | 200 μL |
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| STK39-SCN7A-20-ORAQ | 20 (40 μL) | 200 μL |
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| STK39-SCN7A-20-GORE | 20 (40 μL) | 200 μL |
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| STK39-SCN7A-20-GOOR | 20 (40 μL) | 200 μL |
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| STK39-SCN7A-20-GOGO | 20 (40 μL) | 200 μL |
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| STK39-SCN7A-20-GOGR | 20 (40 μL) | 200 μL |
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| STK39-SCN7A-20-GOAQ | 20 (40 μL) | 200 μL |
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| STK39-SCN7A-20-GRRE | 20 (40 μL) | 200 μL |
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| STK39-SCN7A-20-GROR | 20 (40 μL) | 200 μL |
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| STK39-SCN7A-20-GRGO | 20 (40 μL) | 200 μL |
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| STK39-SCN7A-20-GRGR | 20 (40 μL) | 200 μL |
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| STK39-SCN7A-20-GRAQ | 20 (40 μL) | 200 μL |
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| STK39-SCN7A-20-AQRE | 20 (40 μL) | 200 μL |
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| STK39-SCN7A-20-AQOR | 20 (40 μL) | 200 μL |
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| STK39-SCN7A-20-AQGO | 20 (40 μL) | 200 μL |
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| STK39-SCN7A-20-AQGR | 20 (40 μL) | 200 μL |
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| STK39-SCN7A-20-AQAQ | 20 (40 μL) | 200 μL |
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SCN7A Gene Summary
This gene encodes one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization. This sodium channel protein has some atypical characteristics; the similarity between the human and mouse proteins is lower compared to other orthologous sodium channel pairs. Also, the S4 segments, which sense voltage changes, have fewer positive charged residues that in other sodium channels; domain 4 has fewer arginine and lysine residues compared to other sodium channel proteins. Several alternatively spliced transcript variants exist, but the full-length natures of all of them remain unknown. [provided by RefSeq, Dec 2011]
Gene Name: Sodium Voltage-gated Channel Alpha Subunit 7
Chromosome: CHR2: 167260082 -167343481
Locus: 2q24.3
STK39 Gene Summary
This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008]
Gene Name: Serine/threonine Kinase 39
Chromosome: CHR2: 168810529 -169104105
Locus: 2q24.3
Gene Diseases
The STK39 SCN7A Fusion has been associated with the following diseases:
| Disease Name |
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| Mesothelioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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