STRADA-GRB2 Fusion FISH Probe
The STRADA-GRB2 Fusion FISH Probe is used to confirm a fusion of the STRADA and GRB2 genes. The fusion of the STRADA and GRB2 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| STRADA-GRB2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| STRADA-GRB2-20-RERE | 20 (40 μL) | 200 μL |
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| STRADA-GRB2-20-REOR | 20 (40 μL) | 200 μL |
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| STRADA-GRB2-20-REGO | 20 (40 μL) | 200 μL |
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| STRADA-GRB2-20-REGR | 20 (40 μL) | 200 μL |
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| STRADA-GRB2-20-REAQ | 20 (40 μL) | 200 μL |
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| STRADA-GRB2-20-ORRE | 20 (40 μL) | 200 μL |
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| STRADA-GRB2-20-OROR | 20 (40 μL) | 200 μL |
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| STRADA-GRB2-20-ORGO | 20 (40 μL) | 200 μL |
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| STRADA-GRB2-20-ORAQ | 20 (40 μL) | 200 μL |
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| STRADA-GRB2-20-GORE | 20 (40 μL) | 200 μL |
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| STRADA-GRB2-20-GOOR | 20 (40 μL) | 200 μL |
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| STRADA-GRB2-20-GOGO | 20 (40 μL) | 200 μL |
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| STRADA-GRB2-20-GOGR | 20 (40 μL) | 200 μL |
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| STRADA-GRB2-20-GOAQ | 20 (40 μL) | 200 μL |
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| STRADA-GRB2-20-GRRE | 20 (40 μL) | 200 μL |
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| STRADA-GRB2-20-GROR | 20 (40 μL) | 200 μL |
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| STRADA-GRB2-20-GRGO | 20 (40 μL) | 200 μL |
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| STRADA-GRB2-20-GRGR | 20 (40 μL) | 200 μL |
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| STRADA-GRB2-20-GRAQ | 20 (40 μL) | 200 μL |
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| STRADA-GRB2-20-AQRE | 20 (40 μL) | 200 μL |
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| STRADA-GRB2-20-AQOR | 20 (40 μL) | 200 μL |
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| STRADA-GRB2-20-AQGO | 20 (40 μL) | 200 μL |
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| STRADA-GRB2-20-AQGR | 20 (40 μL) | 200 μL |
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| STRADA-GRB2-20-AQAQ | 20 (40 μL) | 200 μL |
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GRB2 Gene Summary
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Growth Factor Receptor Bound Protein 2
Chromosome: CHR17: 73314156 -73401790
Locus: 17q25.1
STRADA Gene Summary
The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009]
Gene Name: STE20-related Kinase Adaptor Alpha
Chromosome: CHR17: 61780191 -61819330
Locus: 17q23.3
Gene Diseases
The STRADA GRB2 Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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