STX5-WDR74 Fusion FISH Probe
The STX5-WDR74 Fusion FISH Probe is used to confirm a fusion of the STX5 and WDR74 genes. The fusion of the STX5 and WDR74 genes has been associated with Lung Squamous Cell Carcinoma, Lung Adenocarcinoma, Kidney Renal Clear Cell Carcinoma, and Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| STX5-WDR74-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| STX5-WDR74-20-RERE | 20 (40 μL) | 200 μL |
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| STX5-WDR74-20-REOR | 20 (40 μL) | 200 μL |
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| STX5-WDR74-20-REGO | 20 (40 μL) | 200 μL |
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| STX5-WDR74-20-REGR | 20 (40 μL) | 200 μL |
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| STX5-WDR74-20-REAQ | 20 (40 μL) | 200 μL |
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| STX5-WDR74-20-ORRE | 20 (40 μL) | 200 μL |
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| STX5-WDR74-20-OROR | 20 (40 μL) | 200 μL |
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| STX5-WDR74-20-ORGO | 20 (40 μL) | 200 μL |
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| STX5-WDR74-20-ORAQ | 20 (40 μL) | 200 μL |
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| STX5-WDR74-20-GORE | 20 (40 μL) | 200 μL |
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| STX5-WDR74-20-GOOR | 20 (40 μL) | 200 μL |
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| STX5-WDR74-20-GOGO | 20 (40 μL) | 200 μL |
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| STX5-WDR74-20-GOGR | 20 (40 μL) | 200 μL |
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| STX5-WDR74-20-GOAQ | 20 (40 μL) | 200 μL |
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| STX5-WDR74-20-GRRE | 20 (40 μL) | 200 μL |
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| STX5-WDR74-20-GROR | 20 (40 μL) | 200 μL |
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| STX5-WDR74-20-GRGO | 20 (40 μL) | 200 μL |
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| STX5-WDR74-20-GRGR | 20 (40 μL) | 200 μL |
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| STX5-WDR74-20-GRAQ | 20 (40 μL) | 200 μL |
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| STX5-WDR74-20-AQRE | 20 (40 μL) | 200 μL |
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| STX5-WDR74-20-AQOR | 20 (40 μL) | 200 μL |
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| STX5-WDR74-20-AQGO | 20 (40 μL) | 200 μL |
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| STX5-WDR74-20-AQGR | 20 (40 μL) | 200 μL |
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| STX5-WDR74-20-AQAQ | 20 (40 μL) | 200 μL |
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STX5 Gene Summary
This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a critical role in autophagy. Autoantibodies targeting the encoded protein may be a diagnostic marker for endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Gene Name: Syntaxin 5
Chromosome: CHR11: 62574368 -62599560
Locus: 11q12.3
WDR74 Gene Summary
The WD Repeat Domain 74 (WDR74) gene is located on chr11 :62600382-62607628 at 11q12.3.
Gene Name: WD Repeat Domain 74
Chromosome: CHR11: 62600382 -62607628
Locus: 11q12.3
Gene Diseases
The STX5 WDR74 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
| Lung Adenocarcinoma |
| Kidney Renal Clear Cell Carcinoma |
| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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