STXBP6-TMEM189-UBE2V1 Fusion FISH Probe
The STXBP6-TMEM189-UBE2V1 Fusion FISH Probe is used to confirm a fusion of the STXBP6 and TMEM189-UBE2V1 genes. The fusion of the STXBP6 and TMEM189-UBE2V1 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| STXBP6-TMEM189-UBE2V1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| STXBP6-TMEM189-UBE2V1-20-RERE | 20 (40 μL) | 200 μL |
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| STXBP6-TMEM189-UBE2V1-20-REOR | 20 (40 μL) | 200 μL |
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| STXBP6-TMEM189-UBE2V1-20-REGO | 20 (40 μL) | 200 μL |
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| STXBP6-TMEM189-UBE2V1-20-REGR | 20 (40 μL) | 200 μL |
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| STXBP6-TMEM189-UBE2V1-20-REAQ | 20 (40 μL) | 200 μL |
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| STXBP6-TMEM189-UBE2V1-20-ORRE | 20 (40 μL) | 200 μL |
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| STXBP6-TMEM189-UBE2V1-20-OROR | 20 (40 μL) | 200 μL |
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| STXBP6-TMEM189-UBE2V1-20-ORGO | 20 (40 μL) | 200 μL |
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| STXBP6-TMEM189-UBE2V1-20-ORAQ | 20 (40 μL) | 200 μL |
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| STXBP6-TMEM189-UBE2V1-20-GORE | 20 (40 μL) | 200 μL |
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| STXBP6-TMEM189-UBE2V1-20-GOOR | 20 (40 μL) | 200 μL |
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| STXBP6-TMEM189-UBE2V1-20-GOGO | 20 (40 μL) | 200 μL |
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| STXBP6-TMEM189-UBE2V1-20-GOGR | 20 (40 μL) | 200 μL |
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| STXBP6-TMEM189-UBE2V1-20-GOAQ | 20 (40 μL) | 200 μL |
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| STXBP6-TMEM189-UBE2V1-20-GRRE | 20 (40 μL) | 200 μL |
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| STXBP6-TMEM189-UBE2V1-20-GROR | 20 (40 μL) | 200 μL |
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| STXBP6-TMEM189-UBE2V1-20-GRGO | 20 (40 μL) | 200 μL |
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| STXBP6-TMEM189-UBE2V1-20-GRGR | 20 (40 μL) | 200 μL |
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| STXBP6-TMEM189-UBE2V1-20-GRAQ | 20 (40 μL) | 200 μL |
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| STXBP6-TMEM189-UBE2V1-20-AQRE | 20 (40 μL) | 200 μL |
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| STXBP6-TMEM189-UBE2V1-20-AQOR | 20 (40 μL) | 200 μL |
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| STXBP6-TMEM189-UBE2V1-20-AQGO | 20 (40 μL) | 200 μL |
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| STXBP6-TMEM189-UBE2V1-20-AQGR | 20 (40 μL) | 200 μL |
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| STXBP6-TMEM189-UBE2V1-20-AQAQ | 20 (40 μL) | 200 μL |
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STXBP6 Gene Summary
STXBP6 binds components of the SNARE complex (see MIM 603215) and may be involved in regulating SNARE complex formation (Scales et al., 2002 [PubMed 12145319]).[supplied by OMIM, Mar 2008]
Gene Name: Syntaxin Binding Protein 6
Chromosome: CHR14: 25281305 -25519095
Locus: 14q12
TMEM189-UBE2V1 Gene Summary
The TMEM189-UEV mRNA is an infrequent but naturally occurring read-through transcript of the neighboring TMEM189 and UBE2V1 genes. Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein produced by this transcript has UEV1 B domains but the protein is localized to the cytoplasm rather than to the nucleus. The significance of this read-through mRNA and the function of its protein product has not yet been determined. [provided by RefSeq, Oct 2010]
Gene Name: TMEM189-UBE2V1 Readthrough
Chromosome: CHR20: 48697660 -48770335
Locus: 20q13.13
Gene Diseases
The STXBP6 TMEM189-UBE2V1 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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