SUCLA2-CASR Fusion FISH Probe
The SUCLA2-CASR Fusion FISH Probe is used to confirm a fusion of the SUCLA2 and CASR genes. The fusion of the SUCLA2 and CASR genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SUCLA2-CASR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SUCLA2-CASR-20-RERE | 20 (40 μL) | 200 μL |
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| SUCLA2-CASR-20-REOR | 20 (40 μL) | 200 μL |
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| SUCLA2-CASR-20-REGO | 20 (40 μL) | 200 μL |
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| SUCLA2-CASR-20-REGR | 20 (40 μL) | 200 μL |
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| SUCLA2-CASR-20-REAQ | 20 (40 μL) | 200 μL |
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| SUCLA2-CASR-20-ORRE | 20 (40 μL) | 200 μL |
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| SUCLA2-CASR-20-OROR | 20 (40 μL) | 200 μL |
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| SUCLA2-CASR-20-ORGO | 20 (40 μL) | 200 μL |
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| SUCLA2-CASR-20-ORAQ | 20 (40 μL) | 200 μL |
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| SUCLA2-CASR-20-GORE | 20 (40 μL) | 200 μL |
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| SUCLA2-CASR-20-GOOR | 20 (40 μL) | 200 μL |
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| SUCLA2-CASR-20-GOGO | 20 (40 μL) | 200 μL |
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| SUCLA2-CASR-20-GOGR | 20 (40 μL) | 200 μL |
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| SUCLA2-CASR-20-GOAQ | 20 (40 μL) | 200 μL |
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| SUCLA2-CASR-20-GRRE | 20 (40 μL) | 200 μL |
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| SUCLA2-CASR-20-GROR | 20 (40 μL) | 200 μL |
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| SUCLA2-CASR-20-GRGO | 20 (40 μL) | 200 μL |
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| SUCLA2-CASR-20-GRGR | 20 (40 μL) | 200 μL |
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| SUCLA2-CASR-20-GRAQ | 20 (40 μL) | 200 μL |
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| SUCLA2-CASR-20-AQRE | 20 (40 μL) | 200 μL |
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| SUCLA2-CASR-20-AQOR | 20 (40 μL) | 200 μL |
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| SUCLA2-CASR-20-AQGO | 20 (40 μL) | 200 μL |
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| SUCLA2-CASR-20-AQGR | 20 (40 μL) | 200 μL |
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| SUCLA2-CASR-20-AQAQ | 20 (40 μL) | 200 μL |
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CASR Gene Summary
The protein encoded by this gene is a plasma membrane G protein-coupled receptor that senses small changes in circulating calcium concentration. The encoded protein couples this information to intracellular signaling pathways that modify parathyroid hormone secretion or renal cation handling, and thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene are a cause of familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia. [provided by RefSeq, Aug 2017]
Gene Name: Calcium Sensing Receptor
Chromosome: CHR3: 121902529 -122005344
Locus: 3q13.33-q21.1
SUCLA2 Gene Summary
Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq, Jul 2008]
Gene Name: Succinate-CoA Ligase ADP-forming Beta Subunit
Chromosome: CHR13: 48516790 -48575462
Locus: 13q14.2
Gene Diseases
The SUCLA2 CASR Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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