SULF2-BCAS1 Fusion FISH Probe
The SULF2-BCAS1 Fusion FISH Probe is used to confirm a fusion of the SULF2 and BCAS1 genes. The fusion of the SULF2 and BCAS1 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SULF2-BCAS1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SULF2-BCAS1-20-RERE | 20 (40 μL) | 200 μL |
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| SULF2-BCAS1-20-REOR | 20 (40 μL) | 200 μL |
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| SULF2-BCAS1-20-REGO | 20 (40 μL) | 200 μL |
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| SULF2-BCAS1-20-REGR | 20 (40 μL) | 200 μL |
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| SULF2-BCAS1-20-REAQ | 20 (40 μL) | 200 μL |
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| SULF2-BCAS1-20-ORRE | 20 (40 μL) | 200 μL |
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| SULF2-BCAS1-20-OROR | 20 (40 μL) | 200 μL |
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| SULF2-BCAS1-20-ORGO | 20 (40 μL) | 200 μL |
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| SULF2-BCAS1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SULF2-BCAS1-20-GORE | 20 (40 μL) | 200 μL |
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| SULF2-BCAS1-20-GOOR | 20 (40 μL) | 200 μL |
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| SULF2-BCAS1-20-GOGO | 20 (40 μL) | 200 μL |
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| SULF2-BCAS1-20-GOGR | 20 (40 μL) | 200 μL |
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| SULF2-BCAS1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SULF2-BCAS1-20-GRRE | 20 (40 μL) | 200 μL |
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| SULF2-BCAS1-20-GROR | 20 (40 μL) | 200 μL |
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| SULF2-BCAS1-20-GRGO | 20 (40 μL) | 200 μL |
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| SULF2-BCAS1-20-GRGR | 20 (40 μL) | 200 μL |
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| SULF2-BCAS1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SULF2-BCAS1-20-AQRE | 20 (40 μL) | 200 μL |
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| SULF2-BCAS1-20-AQOR | 20 (40 μL) | 200 μL |
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| SULF2-BCAS1-20-AQGO | 20 (40 μL) | 200 μL |
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| SULF2-BCAS1-20-AQGR | 20 (40 μL) | 200 μL |
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| SULF2-BCAS1-20-AQAQ | 20 (40 μL) | 200 μL |
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BCAS1 Gene Summary
This gene resides in a region at 20q13 which is amplified in a variety of tumor types and associated with more aggressive tumor phenotypes. Among the genes identified from this region, it was found to be highly expressed in three amplified breast cancer cell lines and in one breast tumor without amplification at 20q13.2. However, this gene is not in the common region of maximal amplification and its expression was not detected in the breast cancer cell line MCF7, in which this region is highly amplified. Although not consistently expressed, this gene is a candidate oncogene. [provided by RefSeq, Apr 2016]
Gene Name: Breast Carcinoma Amplified Sequence 1
Chromosome: CHR20: 52560078 -52687304
Locus: 20q13.2
SULF2 Gene Summary
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]
Gene Name: Sulfatase 2
Chromosome: CHR20: 46286149 -46415360
Locus: 20q13.12
Gene Diseases
The SULF2 BCAS1 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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