SULF2-GAB2 Fusion FISH Probe
The SULF2-GAB2 Fusion FISH Probe is used to confirm a fusion of the SULF2 and GAB2 genes. The fusion of the SULF2 and GAB2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SULF2-GAB2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SULF2-GAB2-20-RERE | 20 (40 μL) | 200 μL |
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| SULF2-GAB2-20-REOR | 20 (40 μL) | 200 μL |
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| SULF2-GAB2-20-REGO | 20 (40 μL) | 200 μL |
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| SULF2-GAB2-20-REGR | 20 (40 μL) | 200 μL |
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| SULF2-GAB2-20-REAQ | 20 (40 μL) | 200 μL |
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| SULF2-GAB2-20-ORRE | 20 (40 μL) | 200 μL |
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| SULF2-GAB2-20-OROR | 20 (40 μL) | 200 μL |
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| SULF2-GAB2-20-ORGO | 20 (40 μL) | 200 μL |
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| SULF2-GAB2-20-ORAQ | 20 (40 μL) | 200 μL |
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| SULF2-GAB2-20-GORE | 20 (40 μL) | 200 μL |
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| SULF2-GAB2-20-GOOR | 20 (40 μL) | 200 μL |
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| SULF2-GAB2-20-GOGO | 20 (40 μL) | 200 μL |
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| SULF2-GAB2-20-GOGR | 20 (40 μL) | 200 μL |
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| SULF2-GAB2-20-GOAQ | 20 (40 μL) | 200 μL |
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| SULF2-GAB2-20-GRRE | 20 (40 μL) | 200 μL |
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| SULF2-GAB2-20-GROR | 20 (40 μL) | 200 μL |
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| SULF2-GAB2-20-GRGO | 20 (40 μL) | 200 μL |
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| SULF2-GAB2-20-GRGR | 20 (40 μL) | 200 μL |
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| SULF2-GAB2-20-GRAQ | 20 (40 μL) | 200 μL |
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| SULF2-GAB2-20-AQRE | 20 (40 μL) | 200 μL |
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| SULF2-GAB2-20-AQOR | 20 (40 μL) | 200 μL |
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| SULF2-GAB2-20-AQGO | 20 (40 μL) | 200 μL |
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| SULF2-GAB2-20-AQGR | 20 (40 μL) | 200 μL |
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| SULF2-GAB2-20-AQAQ | 20 (40 μL) | 200 μL |
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GAB2 Gene Summary
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
Gene Name: GRB2 Associated Binding Protein 2
Chromosome: CHR11: 77926335 -78128868
Locus: 11q14.1
SULF2 Gene Summary
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]
Gene Name: Sulfatase 2
Chromosome: CHR20: 46286149 -46415360
Locus: 20q13.12
Gene Diseases
The SULF2 GAB2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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