SUPT16H-CHD8 Fusion FISH Probe
The SUPT16H-CHD8 Fusion FISH Probe is used to confirm a fusion of the SUPT16H and CHD8 genes. The fusion of the SUPT16H and CHD8 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SUPT16H-CHD8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SUPT16H-CHD8-20-RERE | 20 (40 μL) | 200 μL |
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| SUPT16H-CHD8-20-REOR | 20 (40 μL) | 200 μL |
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| SUPT16H-CHD8-20-REGO | 20 (40 μL) | 200 μL |
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| SUPT16H-CHD8-20-REGR | 20 (40 μL) | 200 μL |
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| SUPT16H-CHD8-20-REAQ | 20 (40 μL) | 200 μL |
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| SUPT16H-CHD8-20-ORRE | 20 (40 μL) | 200 μL |
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| SUPT16H-CHD8-20-OROR | 20 (40 μL) | 200 μL |
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| SUPT16H-CHD8-20-ORGO | 20 (40 μL) | 200 μL |
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| SUPT16H-CHD8-20-ORAQ | 20 (40 μL) | 200 μL |
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| SUPT16H-CHD8-20-GORE | 20 (40 μL) | 200 μL |
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| SUPT16H-CHD8-20-GOOR | 20 (40 μL) | 200 μL |
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| SUPT16H-CHD8-20-GOGO | 20 (40 μL) | 200 μL |
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| SUPT16H-CHD8-20-GOGR | 20 (40 μL) | 200 μL |
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| SUPT16H-CHD8-20-GOAQ | 20 (40 μL) | 200 μL |
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| SUPT16H-CHD8-20-GRRE | 20 (40 μL) | 200 μL |
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| SUPT16H-CHD8-20-GROR | 20 (40 μL) | 200 μL |
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| SUPT16H-CHD8-20-GRGO | 20 (40 μL) | 200 μL |
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| SUPT16H-CHD8-20-GRGR | 20 (40 μL) | 200 μL |
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| SUPT16H-CHD8-20-GRAQ | 20 (40 μL) | 200 μL |
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| SUPT16H-CHD8-20-AQRE | 20 (40 μL) | 200 μL |
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| SUPT16H-CHD8-20-AQOR | 20 (40 μL) | 200 μL |
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| SUPT16H-CHD8-20-AQGO | 20 (40 μL) | 200 μL |
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| SUPT16H-CHD8-20-AQGR | 20 (40 μL) | 200 μL |
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| SUPT16H-CHD8-20-AQAQ | 20 (40 μL) | 200 μL |
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SUPT16H Gene Summary
Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]
Gene Name: SPT16 Homolog, Facilitates Chromatin Remodeling Subunit
Chromosome: CHR14: 21819630 -21852425
Locus: 14q11.2
CHD8 Gene Summary
This gene encodes a member of the chromodomain-helicase-DNA binding protein family, which is characterized by a SNF2-like domain and two chromatin organization modifier domains. The encoded protein also contains brahma and kismet domains, which are common to the subfamily of chromodomain-helicase-DNA binding proteins to which this protein belongs. This gene has been shown to function in several processes that include transcriptional regulation, epigenetic remodeling, promotion of cell proliferation, and regulation of RNA synthesis. Allelic variants of this gene are associated with autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2016]
Gene Name: Chromodomain Helicase DNA Binding Protein 8
Chromosome: CHR14: 21853352 -21905457
Locus: 14q11.2
Gene Diseases
The SUPT16H CHD8 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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