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SVIL-STAM Fusion FISH Probe

The SVIL-STAM Fusion FISH Probe is used to confirm a fusion of the SVIL and STAM genes. The fusion of the SVIL and STAM genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
SVIL-STAM-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
SVIL-STAM-20-RERE 20 (40 μL) 200 μL
SVIL-STAM-20-REOR 20 (40 μL) 200 μL
SVIL-STAM-20-REGO 20 (40 μL) 200 μL
SVIL-STAM-20-REGR 20 (40 μL) 200 μL
SVIL-STAM-20-REAQ 20 (40 μL) 200 μL
SVIL-STAM-20-ORRE 20 (40 μL) 200 μL
SVIL-STAM-20-OROR 20 (40 μL) 200 μL
SVIL-STAM-20-ORGO 20 (40 μL) 200 μL
SVIL-STAM-20-ORAQ 20 (40 μL) 200 μL
SVIL-STAM-20-GORE 20 (40 μL) 200 μL
SVIL-STAM-20-GOOR 20 (40 μL) 200 μL
SVIL-STAM-20-GOGO 20 (40 μL) 200 μL
SVIL-STAM-20-GOGR 20 (40 μL) 200 μL
SVIL-STAM-20-GOAQ 20 (40 μL) 200 μL
SVIL-STAM-20-GRRE 20 (40 μL) 200 μL
SVIL-STAM-20-GROR 20 (40 μL) 200 μL
SVIL-STAM-20-GRGO 20 (40 μL) 200 μL
SVIL-STAM-20-GRGR 20 (40 μL) 200 μL
SVIL-STAM-20-GRAQ 20 (40 μL) 200 μL
SVIL-STAM-20-AQRE 20 (40 μL) 200 μL
SVIL-STAM-20-AQOR 20 (40 μL) 200 μL
SVIL-STAM-20-AQGO 20 (40 μL) 200 μL
SVIL-STAM-20-AQGR 20 (40 μL) 200 μL
SVIL-STAM-20-AQAQ 20 (40 μL) 200 μL

SVIL Gene Summary

This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Several transcript variants encoding different isoforms of supervillin have been described. [provided by RefSeq, Apr 2016]

Gene Name: Supervillin

Chromosome: CHR10: 29746276 -30024730

Locus: 10p11.23

STAM Gene Summary

This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]

Gene Name: Signal Transducing Adaptor Molecule

Chromosome: CHR10: 17686123 -17758821

Locus: 10p12.33

Gene Diseases

The SVIL STAM Fusion has been associated with the following diseases:

Disease Name
Sarcoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.