SYNE2-ACTN1 Fusion FISH Probe
The SYNE2-ACTN1 Fusion FISH Probe is used to confirm a fusion of the SYNE2 and ACTN1 genes. The fusion of the SYNE2 and ACTN1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SYNE2-ACTN1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| SYNE2-ACTN1-20-RERE | 20 (40 μL) | 200 μL |
|
|
| SYNE2-ACTN1-20-REOR | 20 (40 μL) | 200 μL |
|
|
| SYNE2-ACTN1-20-REGO | 20 (40 μL) | 200 μL |
|
|
| SYNE2-ACTN1-20-REGR | 20 (40 μL) | 200 μL |
|
|
| SYNE2-ACTN1-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| SYNE2-ACTN1-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| SYNE2-ACTN1-20-OROR | 20 (40 μL) | 200 μL |
|
|
| SYNE2-ACTN1-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| SYNE2-ACTN1-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| SYNE2-ACTN1-20-GORE | 20 (40 μL) | 200 μL |
|
|
| SYNE2-ACTN1-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| SYNE2-ACTN1-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| SYNE2-ACTN1-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| SYNE2-ACTN1-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| SYNE2-ACTN1-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| SYNE2-ACTN1-20-GROR | 20 (40 μL) | 200 μL |
|
|
| SYNE2-ACTN1-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| SYNE2-ACTN1-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| SYNE2-ACTN1-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| SYNE2-ACTN1-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| SYNE2-ACTN1-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| SYNE2-ACTN1-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| SYNE2-ACTN1-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| SYNE2-ACTN1-20-AQAQ | 20 (40 μL) | 200 μL |
|
ACTN1 Gene Summary
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Actinin Alpha 1
Chromosome: CHR14: 69340839 -69446083
Locus: 14q22-q24
SYNE2 Gene Summary
The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Name: Spectrin Repeat Containing Nuclear Envelope Protein 2
Chromosome: CHR14: 64319682 -64693167
Locus: 14q23.2
Gene Diseases
The SYNE2 ACTN1 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|