SYNGAP1-COL11A2 Fusion FISH Probe
The SYNGAP1-COL11A2 Fusion FISH Probe is used to confirm a fusion of the SYNGAP1 and COL11A2 genes. The fusion of the SYNGAP1 and COL11A2 genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SYNGAP1-COL11A2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SYNGAP1-COL11A2-20-RERE | 20 (40 μL) | 200 μL |
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| SYNGAP1-COL11A2-20-REOR | 20 (40 μL) | 200 μL |
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| SYNGAP1-COL11A2-20-REGO | 20 (40 μL) | 200 μL |
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| SYNGAP1-COL11A2-20-REGR | 20 (40 μL) | 200 μL |
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| SYNGAP1-COL11A2-20-REAQ | 20 (40 μL) | 200 μL |
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| SYNGAP1-COL11A2-20-ORRE | 20 (40 μL) | 200 μL |
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| SYNGAP1-COL11A2-20-OROR | 20 (40 μL) | 200 μL |
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| SYNGAP1-COL11A2-20-ORGO | 20 (40 μL) | 200 μL |
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| SYNGAP1-COL11A2-20-ORAQ | 20 (40 μL) | 200 μL |
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| SYNGAP1-COL11A2-20-GORE | 20 (40 μL) | 200 μL |
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| SYNGAP1-COL11A2-20-GOOR | 20 (40 μL) | 200 μL |
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| SYNGAP1-COL11A2-20-GOGO | 20 (40 μL) | 200 μL |
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| SYNGAP1-COL11A2-20-GOGR | 20 (40 μL) | 200 μL |
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| SYNGAP1-COL11A2-20-GOAQ | 20 (40 μL) | 200 μL |
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| SYNGAP1-COL11A2-20-GRRE | 20 (40 μL) | 200 μL |
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| SYNGAP1-COL11A2-20-GROR | 20 (40 μL) | 200 μL |
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| SYNGAP1-COL11A2-20-GRGO | 20 (40 μL) | 200 μL |
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| SYNGAP1-COL11A2-20-GRGR | 20 (40 μL) | 200 μL |
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| SYNGAP1-COL11A2-20-GRAQ | 20 (40 μL) | 200 μL |
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| SYNGAP1-COL11A2-20-AQRE | 20 (40 μL) | 200 μL |
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| SYNGAP1-COL11A2-20-AQOR | 20 (40 μL) | 200 μL |
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| SYNGAP1-COL11A2-20-AQGO | 20 (40 μL) | 200 μL |
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| SYNGAP1-COL11A2-20-AQGR | 20 (40 μL) | 200 μL |
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| SYNGAP1-COL11A2-20-AQAQ | 20 (40 μL) | 200 μL |
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COL11A2 Gene Summary
This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. It is located on chromosome 6 very close to but separate from the gene for retinoid X receptor beta. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Proteolytic processing of this type XI chain produces PARP, a proline/arginine-rich protein that is an amino terminal domain. Mutations in this gene are associated with type III Stickler syndrome, otospondylomegaepiphyseal dysplasia (OSMED syndrome), Weissenbacher-Zweymuller syndrome, autosomal dominant non-syndromic sensorineural type 13 deafness (DFNA13), and autosomal recessive non-syndromic sensorineural type 53 deafness (DFNB53). Alternative splicing results in multiple transcript variants. A related pseudogene is located nearby on chromosome 6. [provided by RefSeq, Jul 2009]
Gene Name: Collagen Type XI Alpha 2 Chain
Chromosome: CHR6_dbb_hap3: 4411775 -4441552
Locus: 6p21.32
SYNGAP1 Gene Summary
This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Allelic variants of this gene are associated with intellectual disability and autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Gene Name: Synaptic Ras GTPase Activating Protein 1
Chromosome: CHR6: 33387846 -33421466
Locus: 6p21.32
Gene Diseases
The SYNGAP1 COL11A2 Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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