SYT14-HSD11B1 Fusion FISH Probe
The SYT14-HSD11B1 Fusion FISH Probe is used to confirm a fusion of the SYT14 and HSD11B1 genes. The fusion of the SYT14 and HSD11B1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SYT14-HSD11B1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SYT14-HSD11B1-20-RERE | 20 (40 μL) | 200 μL |
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| SYT14-HSD11B1-20-REOR | 20 (40 μL) | 200 μL |
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| SYT14-HSD11B1-20-REGO | 20 (40 μL) | 200 μL |
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| SYT14-HSD11B1-20-REGR | 20 (40 μL) | 200 μL |
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| SYT14-HSD11B1-20-REAQ | 20 (40 μL) | 200 μL |
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| SYT14-HSD11B1-20-ORRE | 20 (40 μL) | 200 μL |
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| SYT14-HSD11B1-20-OROR | 20 (40 μL) | 200 μL |
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| SYT14-HSD11B1-20-ORGO | 20 (40 μL) | 200 μL |
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| SYT14-HSD11B1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SYT14-HSD11B1-20-GORE | 20 (40 μL) | 200 μL |
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| SYT14-HSD11B1-20-GOOR | 20 (40 μL) | 200 μL |
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| SYT14-HSD11B1-20-GOGO | 20 (40 μL) | 200 μL |
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| SYT14-HSD11B1-20-GOGR | 20 (40 μL) | 200 μL |
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| SYT14-HSD11B1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SYT14-HSD11B1-20-GRRE | 20 (40 μL) | 200 μL |
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| SYT14-HSD11B1-20-GROR | 20 (40 μL) | 200 μL |
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| SYT14-HSD11B1-20-GRGO | 20 (40 μL) | 200 μL |
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| SYT14-HSD11B1-20-GRGR | 20 (40 μL) | 200 μL |
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| SYT14-HSD11B1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SYT14-HSD11B1-20-AQRE | 20 (40 μL) | 200 μL |
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| SYT14-HSD11B1-20-AQOR | 20 (40 μL) | 200 μL |
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| SYT14-HSD11B1-20-AQGO | 20 (40 μL) | 200 μL |
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| SYT14-HSD11B1-20-AQGR | 20 (40 μL) | 200 μL |
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| SYT14-HSD11B1-20-AQAQ | 20 (40 μL) | 200 μL |
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HSD11B1 Gene Summary
The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011]
Gene Name: Hydroxysteroid 11-beta Dehydrogenase 1
Chromosome: CHR1: 209859524 -209908295
Locus: 1q32.2
SYT14 Gene Summary
This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate membrane trafficking in synaptic transmission. The encoded protein is a calcium-independent synaptotagmin. Mutations in this gene are a cause of autosomal recessive spinocerebellar ataxia-11 (SCAR11), and a t(1;3) translocation of this gene has been associated with neurodevelopmental abnormalities. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Dec 2011]
Gene Name: Synaptotagmin 14
Chromosome: CHR1: 210111537 -210337633
Locus: 1q32.2
Gene Diseases
The SYT14 HSD11B1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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