SYT7-FADS3 Fusion FISH Probe
The SYT7-FADS3 Fusion FISH Probe is used to confirm a fusion of the SYT7 and FADS3 genes. The fusion of the SYT7 and FADS3 genes has been associated with Cholangiocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SYT7-FADS3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SYT7-FADS3-20-RERE | 20 (40 μL) | 200 μL |
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| SYT7-FADS3-20-REOR | 20 (40 μL) | 200 μL |
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| SYT7-FADS3-20-REGO | 20 (40 μL) | 200 μL |
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| SYT7-FADS3-20-REGR | 20 (40 μL) | 200 μL |
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| SYT7-FADS3-20-REAQ | 20 (40 μL) | 200 μL |
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| SYT7-FADS3-20-ORRE | 20 (40 μL) | 200 μL |
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| SYT7-FADS3-20-OROR | 20 (40 μL) | 200 μL |
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| SYT7-FADS3-20-ORGO | 20 (40 μL) | 200 μL |
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| SYT7-FADS3-20-ORAQ | 20 (40 μL) | 200 μL |
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| SYT7-FADS3-20-GORE | 20 (40 μL) | 200 μL |
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| SYT7-FADS3-20-GOOR | 20 (40 μL) | 200 μL |
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| SYT7-FADS3-20-GOGO | 20 (40 μL) | 200 μL |
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| SYT7-FADS3-20-GOGR | 20 (40 μL) | 200 μL |
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| SYT7-FADS3-20-GOAQ | 20 (40 μL) | 200 μL |
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| SYT7-FADS3-20-GRRE | 20 (40 μL) | 200 μL |
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| SYT7-FADS3-20-GROR | 20 (40 μL) | 200 μL |
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| SYT7-FADS3-20-GRGO | 20 (40 μL) | 200 μL |
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| SYT7-FADS3-20-GRGR | 20 (40 μL) | 200 μL |
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| SYT7-FADS3-20-GRAQ | 20 (40 μL) | 200 μL |
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| SYT7-FADS3-20-AQRE | 20 (40 μL) | 200 μL |
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| SYT7-FADS3-20-AQOR | 20 (40 μL) | 200 μL |
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| SYT7-FADS3-20-AQGO | 20 (40 μL) | 200 μL |
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| SYT7-FADS3-20-AQGR | 20 (40 μL) | 200 μL |
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| SYT7-FADS3-20-AQAQ | 20 (40 μL) | 200 μL |
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FADS3 Gene Summary
The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. [provided by RefSeq, Jul 2008]
Gene Name: Fatty Acid Desaturase 3
Chromosome: CHR11: 61640997 -61659006
Locus: 11q12.2
SYT7 Gene Summary
This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. A similar protein in rodents mediates hormone secretion and lysosome exocytosis. In humans, expression of this gene has been associated with prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Synaptotagmin 7
Chromosome: CHR11: 61282784 -61348298
Locus: 11q12.2
Gene Diseases
The SYT7 FADS3 Fusion has been associated with the following diseases:
| Disease Name |
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| Cholangiocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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